Interaction of chlorpromazine with phospholipid membranes: A monolayer and a microelectrophoresis approach

被引：16

作者：

Bennouna, M

FerreiraMarques, J

Banerjee, S

Caspers, J

Ruysschaert, JM

机构：

[1] FREE UNIV BRUSSELS,CHIM PHYS MACROMOL INTERFACES LAB,B-1050 BRUSSELS,BELGIUM

[2] UNIV ABDELMALEK ESAADI,FAC SCI TETOUAN,TETOUAN,MOROCCO

来源：

LANGMUIR | 1997年 / 13卷 / 24期

关键词：

D O I：

10.1021/la970203+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chlorpromazine penetration into the lipid core of the membrane was demonstrated through measurements on lipid monolayers (surface pressure and surface potential). The surface pressure measurements allow us to calculate the intrinsic binding constant (partition coefficient) for the lipid-Chlorpromazine interaction. This latter value is in correct agreement with the obtained results by electrophoretic mobilities measurements on liposomes.

引用

收藏

页码：6533 / 6539

页数：7

相关论文

共 42 条

[11] EVIDENCE OF A SPECIFIC COMPLEX BETWEEN ADRIAMYCIN AND NEGATIVELY-CHARGED PHOSPHOLIPIDS [J].

GOORMAGHTIGH, E ;

CHATELAIN, P ;

CASPERS, J ;

RUYSSCHAERT, JM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 597 (01) :1-14

[12] EVALUATION OF THE ANESTHETIC LIPID ASSOCIATION CONSTANT - A MONOLAYER APPROACH [J].

GUILMIN, T ;

GOORMAGHTIGH, E ;

BRASSEUR, R ;

CASPERS, J ;

RUYSSCHAERT, JM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 685 (02) :169-176

[13] SURFACE CHARGE, SURFACE DIPOLES AND MEMBRANE CONDUCTANCE [J].

HAYDON, DA ;

MYERS, VB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 307 (03) :429-443

[14]

JAMES AM, 1978, SURF COLLOID SCI, V2, P121

[15] INTERACTION OF MELITTIN WITH PHOSPHATIDYLCHOLINE MEMBRANES - BINDING ISOTHERM AND LIPID HEADGROUP CONFORMATION [J].

KUCHINKA, E ;

SEELIG, J .

BIOCHEMISTRY, 1989, 28 (10) :4216-4221

[16] MEMBRANE CONCENTRATION OF A LOCAL ANESTHETIC (CHLORPROMAZINE) [J].

KWANT, WO ;

SEEMAN, P .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 183 (03) :530-&

[17]

LEE AG, 1977, MOL PHARMACOL, V13, P474

[18] INTERACTION OF CHLORPROMAZINE WITH BIOLOGICAL-MEMBRANES - PHOTOCHEMICAL STUDY USING SPIN LABELS [J].

LETERRIER, F ;

MENDYK, A ;

VIRET, J .

BIOCHEMICAL PHARMACOLOGY, 1976, 25 (22) :2469-2474

[19] MEMBRANE SOLUBILITY OF CHLORPROMAZINE - HYGROSCOPIC DESORPTION AND CENTRIFUGATION METHODS YIELD COMPARABLE RESULTS [J].

LUXNAT, M ;

MULLER, HJ ;

GALLA, HJ .

BIOCHEMICAL JOURNAL, 1984, 224 (03) :1023-1026

[20] PARTITION OF CHLORPROMAZINE INTO LIPID BILAYER-MEMBRANES - THE EFFECT OF MEMBRANE-STRUCTURE AND COMPOSITION [J].

LUXNAT, M ;

GALLA, HJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 856 (02) :274-282

← 1 2 3 4 5 →