The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review

被引：71

作者：

Fowdar, Kaushal ^{[1
]}

Chen, Huan ^{[1
]}

He, Zhiyi ^{[1
]}

Zhang, Jiujin ^{[2
]}

Zhong, Xiaoning ^{[1
]}

Zhang, Jianquan ^{[1
]}

Li, Meihua ^{[1
]}

Bai, Jing ^{[1
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Resp Med, Nanning 530021, Peoples R China

[2] First Peoples Hosp Yulin City, Dept Resp Med, Yulin 537000, Peoples R China

来源：

HEART & LUNG | 2017年 / 46卷 / 02期

关键词：

Chronic obstructive pulmonary disease; Effect; N-acetylcysteine; Meta-analysis; Exacerbation; PLACEBO-CONTROLLED TRIAL; LONG-TERM TREATMENT; CHRONIC-BRONCHITIS; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; DOUBLE-BLIND; STABLE COPD; PANTHEON;

D O I：

10.1016/j.hrtlng.2016.12.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

N-acetylcysteine (NAC) is an antioxidant and anti-inflammatory. Its effects on chronic obstructive pulmonary (COPD) outcomes, including exacerbation of and changes in lung function parameters, are controversial. To investigate the effects of NAC on COPD exacerbation and changes in lung function parameters in patients with COPD. A meta-analysis of randomized controlled trials retrieved from PubMed and Medline databases (12 trials; 2691 patients). High-dose [relative ratio (RR) = 0.90, 95% confidence interval (CI) = 0.82-0.996, P = 0.041] and low-dose (RR = 0.83, 95% CI = 0.69-0.99, P = 0.043) NAC reduced COPD exacerbation prevalence. Long-term (>= 6 months), but not short-term, NAC reduced exacerbation prevalence (RR = 0.85, 95% CI = 0.74-0.98, P = 0.024). NAC did not affect exacerbation rate, forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), or inspiratory capacity (IC). Long-term NAC therapy may reduce risk of COPD exacerbation. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：120 / 128

页数：9

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