Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT

被引：970

作者：

Robertson, C. A. ^{[1
]}

Evans, D. Hawkins ^{[1
]}

Abraharnse, H. ^{[1
]}

机构：

[1] Univ Johannesburg, Laser Res Grp, ZA-2028 Johannesburg, South Africa

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2009年 / 96卷 / 01期

关键词：

Photodynamic therapy; PDT mechanisms; Photosensitizers; Photochemistry; Cellular mechanisms; Tumor destruction; MESSENGER-RNA; HUMAN SKIN; MELANOMA; DEATH; MODES; EXPRESSION; HISTORY;

D O I：

10.1016/j.jphotobiol.2009.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic therapy (PDT) has been used for many years, but it is only now becoming widely accepted and utilized. Originally it was developed as a tumor therapy and some of its most successful applications are for non-malignant diseases. This article provides a broad review of different parameters used and mechanisms instituted in PDT such as photosensitizers (PS), photochemistry and photophysics, cellular localization, cellular signaling, cell metabolism and modes of cell death that operate on a cellular level, as well as photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. These specific cellular mechanisms are most commonly applied in PDT and for the most part are often researched and exploited. If the combination of these specific parameters and mechanisms can be optimized within PDT it could possibly be used as a suitable alternative for the treatment and management of specific cancers. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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