SK-ER3 neuroblastoma cells as a model for the study of estrogen influence on neural cells

被引：36

作者：

Agrati, P ^{[1
]}

Garnier, M ^{[1
]}

Patrone, C ^{[1
]}

Pollio, G ^{[1
]}

Santagati, S ^{[1
]}

Vegeto, E ^{[1
]}

Maggi, A ^{[1
]}

机构：

[1] UNIV MILAN, INST PHARMACOL SCI, CTR MPL, I-20133 MILAN, ITALY

来源：

BRAIN RESEARCH BULLETIN | 1997年 / 44卷 / 04期

关键词：

neuroblastoma; stable transfection; estrogen receptor; differentiation; brain;

D O I：

10.1016/S0361-9230(97)00237-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuroblastoma SK-ER3 cell line obtained by stable transfection of the human SK-N-BE cell line is proposed as a model for the study of estrogen receptor activity in cells of neural origin, In the SK-ER3 cell line the estrogen receptor, once activated, initiates a differentiation program leading to growth arrest, morphological changes, and acquisition of the dopaminergic phenotype, In the absence of estrogens, this program can be triggered by IGF-I, which can activate the unliganded estrogen receptor via the ras-pathway, It is proposed that this model system might recapitulate the events occurring in vivo during the differentiation of the nervous system and that IGF-I may play an important role in the activation of estrogen receptor at the very early stage of brain development affecting the differentiation of a number of hypothalamic and extrahypothalamic brain regions. (C) 1997 Elsevier Science Inc.

引用

页码：519 / 523

页数：5

共 19 条

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