The Making of an siRNA

被引：4

作者：

Pham, JW ^{[1
]}

Sontheimer, EJ ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

MOLECULAR CELL | 2004年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.molcel.2004.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An array of gene silencing pathways share a common early step: Dicer cleaves double-stranded RNA (dsRNA) into similar to20-25 nucleotide fragments that direct the silencing machinery to specific targets. A recent report in Cell reveals how Dicer's two RNase III domains collaborate during dsRNA processing and sets the stage for a deeper understanding of Dicer's roles in later phases of silencing complex assembly.

引用

页码：163 / 164

页数：2

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