Signal transduction - Rhomantic interludes raise blood pressure

被引：37

作者：

Somlyo, AP

机构：

[1] UNIV VIRGINIA,DEPT BIOL PHYS,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,DEPT INTERNAL MED CARDIOL,CHARLOTTESVILLE,VA 22908

[3] UNIV VIRGINIA,CTR STRUCT BIOL,CHARLOTTESVILLE,VA 22908

来源：

NATURE | 1997年 / 389卷 / 6654期

关键词：

D O I：

10.1038/40002

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Calcium is a crucial player in the contraction of both smooth and striated muscle. Smooth muscles regulate the size of the lumen of many different vessels including the arteries, airways, and gut, and so their abnormal contraction can cause diseases such as asthma or high blood pressure. A new drug called Y-27632, which specifically inhibits the Rho-associated kinases, renders smooth muscles less sensitive to calcium. Furthermore, this drug is able to reduce high blood pressure in animals. However, its benefits in treating patients with high blood pressure have yet to be elucidated.

引用

收藏

页码：908 / &

页数：3

相关论文

共 18 条

[1] Focal adhesions, contractility, and signaling [J].

Burridge, K ;

ChrzanowskaWodnicka, M .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :463-518

[2] Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B [J].

Fujihara, H ;

Walker, LA ;

Gong, MC ;

Lemichez, E ;

Boquet, P ;

Somlyo, AV ;

Somlyo, AP .

MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (12) :2437-2447

[3] Myosin light chain kinases [J].

Gallagher, PJ ;

Herring, BP ;

Stull, JT .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 1997, 18 (01) :1-16

[4] Role of guanine nucleotide-binding proteins ras-family or trimeric proteins or both in Ca2+ sensitization of smooth muscle [J].

Gong, MC ;

Iizuka, K ;

Nixon, G ;

Browne, JP ;

Hall, A ;

Eccleston, JF ;

Sugai, M ;

Kobayashi, S ;

Somlyo, AV ;

Somlyo, AP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (03) :1340-1345

[5]

Gong MC, 1997, J BIOL CHEM, V272, P10704

[6] SMALL GTP-BINDING PROTEINS AND THE REGULATION OF THE ACTIN CYTOSKELETON [J].

HALL, A .

ANNUAL REVIEW OF CELL BIOLOGY, 1994, 10 :31-54

[7]

Hartshorne D. J., 1987, PHYSL GASTROINTESTIN, P423

[8] The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue [J].

Hirshberg, M ;

Stockley, RW ;

Dodson, G ;

Webb, MR .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (02) :147-152

[9]

Ichikawa K, 1996, J BIOL CHEM, V271, P4733

[10] Regulation of myosin phosphatase by Rho and Rho-Associated kinase (Rho-kinase) [J].

Kimura, K ;

Ito, M ;

Amano, M ;

Chihara, K ;

Fukata, Y ;

Nakafuku, M ;

Yamamori, B ;

Feng, JH ;

Nakano, T ;

Okawa, K ;

Iwamatsu, A ;

Kaibuchi, K .

SCIENCE, 1996, 273 (5272) :245-248