A general route to 4-imidazolyl-containing multidentate ligands for biomimetic studies

被引:13
作者
Collman, JP [1 ]
Zhong, M [1 ]
Wang, Z [1 ]
机构
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
关键词
D O I
10.1021/ol990201b
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] 4-Iodo-1-tritylimidazole undergoes magnesium-iodine exchange with a Grignard reagent to give selectively the 4-magnesioimidazole derivative, which reacts with esters to form a variety of poly-4-imidazolyl carbinol compounds in 40-79% yields. A wide range of bi-, tri-, and pentadentate ligands featuring 4-substituted imidazole units have been efficiently synthesized.
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收藏
页码:949 / 951
页数:3
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