Manganese-induced apoptosis in PC12 cells

被引：100

作者：

Hirata, Y ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan

[2] RIKEN, Lab Genes Motor Syst, Biomimet Control Res Ctr, Nagoya, Aichi 4630003, Japan

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 2002年 / 24卷 / 05期

关键词：

apoptosis; manganese; Parkinson's disease; JNK; MAPK; p38; p70; S6; kinase; Bcl-2; caspase;

D O I：

10.1016/S0892-0362(02)00215-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：639 / 653

页数：15

共 70 条

[61]

STREHLER BL, 1954, METHOD BIOCHEM ANAL, V1, P341

[62] FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 [J].

Tan, Y ;

Rouse, J ;

Zhang, AH ;

Cariati, S ;

Cohen, P ;

Comb, MJ .

EMBO JOURNAL, 1996, 15 (17) :4629-4642

[63] In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining [J].

Tatton, NA ;

Kish, SJ .

NEUROSCIENCE, 1997, 77 (04) :1037-1048

[64]

TILLY BC, 1993, J BIOL CHEM, V268, P19919

[65] STUDIES ON THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - INHIBITION OF NAD-LINKED SUBSTRATE OXIDATION BY ITS METABOLITE, 1-METHYL-4-PHENYLPYRIDINIUM [J].

VYAS, I ;

HEIKKILA, RE ;

NICKLAS, WJ .

JOURNAL OF NEUROCHEMISTRY, 1986, 46 (05) :1501-1507

[66]

Walowitz JL, 1999, J NEUROSCI RES, V57, P847, DOI 10.1002/(SICI)1097-4547(19990915)57:6<847::AID-JNR10>3.3.CO

[67]

2-M

[68] OPPOSING EFFECTS OF ERK AND JNK-P38 MAP KINASES ON APOPTOSIS [J].

XIA, ZG ;

DICKENS, M ;

RAINGEAUD, J ;

DAVIS, RJ ;

GREENBERG, ME .

SCIENCE, 1995, 270 (5240) :1326-1331

[69] Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3T3 cells [J].

Xue, LZ ;

Lucocq, JM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (02) :236-242

[70]

METHOD ENZYMOL

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