Pathogen-derived immunomodulatory molecules: future immunotherapeutics?

被引：63

作者：

Fallon, Padraic G. ^{[1
]}

Alcami, Antonio

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

[2] CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

[3] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.it.2006.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of molecules from various pathogens that modulate innate and/or adaptive immunity is a dynamic and rapidly developing area of research. These immunomodulatory molecules (IM) have been optimized during pathogen-host co-evolution, and have a potential application as novel immunotherapeutics. In this review, we illustrate the use of pathogen IM that have been produced as recombinant proteins, with different modes of modulatory activity, and discuss their potential to modulate undesirable immune responses in human diseases.

引用

页码：470 / 476

页数：7

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