Pathogen-derived immunomodulatory molecules: future immunotherapeutics?

被引：63

作者：

Fallon, Padraic G. ^{[1
]}

Alcami, Antonio

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

[2] CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

[3] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.it.2006.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of molecules from various pathogens that modulate innate and/or adaptive immunity is a dynamic and rapidly developing area of research. These immunomodulatory molecules (IM) have been optimized during pathogen-host co-evolution, and have a potential application as novel immunotherapeutics. In this review, we illustrate the use of pathogen IM that have been produced as recombinant proteins, with different modes of modulatory activity, and discuss their potential to modulate undesirable immune responses in human diseases.

引用

页码：470 / 476

页数：7

共 78 条

[31] Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models [J].

Liu, D ;

Dai, E ;

Miller, L ;

Seet, B ;

Lalani, A ;

Macauley, C ;

Li, X ;

Virgin, HW ;

Bunce, C ;

Turner, P ;

Moyer, R ;

McFadden, G ;

Lucas, A .

TRANSPLANTATION, 2004, 77 (11) :1652-1660

[32] The viral anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury [J].

Liu, LY ;

Lalani, A ;

Dai, EB ;

Seet, B ;

Macauley, C ;

Singh, R ;

Fan, L ;

McFadden, G ;

Lucas, A .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (11) :1613-1621

[33] Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis [J].

Lucas, A ;

Dai, EB ;

Liu, LY ;

Guan, HY ;

Nash, P ;

McFadden, G ;

Miller, L .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2000, 19 (11) :1029-1038

[34] Secreted immunomodulatory viral proteins as novel biotherapeutics [J].

Lucas, A ;

McFadden, G .

JOURNAL OF IMMUNOLOGY, 2004, 173 (08) :4765-4774

[35] Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty [J].

Lucas, A ;

Liu, LY ;

Macen, J ;

Nash, P ;

Dai, E ;

Stewart, M ;

Graham, K ;

Etches, W ;

Boshkov, L ;

Nation, PN ;

Humen, D ;

Hobman, ML ;

McFadden, G .

CIRCULATION, 1996, 94 (11) :2890-2900

[36] A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression [J].

Macagno, Annalisa ;

Molteni, Monica ;

Rinaldi, Andrea ;

Bertoni, Francesco ;

Lanzavecchia, Antonio ;

Rossetti, Carlo ;

Sallusto, Federica .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (06) :1481-1492

[37] Helminth parasites - masters of regulation [J].

Maizels, RM ;

Balic, A ;

Gomez-Escobar, N ;

Nair, M ;

Taylor, MD ;

Allen, JE .

IMMUNOLOGICAL REVIEWS, 2004, 201 :89-116

[38]

Maksymowych WP, 1996, J RHEUMATOL, V23, P878

[39] Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10 [J].

Maloney, G ;

Schröder, M ;

Bowie, AG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (35) :30838-30844

[40] An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system [J].

Mazmanian, SK ;

Liu, CH ;

Tzianabos, AO ;

Kasper, DL .

CELL, 2005, 122 (01) :107-118

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