Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

被引：1172

作者：

Muller, Patricia A. J. ^{[1
]}

Vousden, Karen H. ^{[2
]}

机构：

[1] MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

[2] CR UK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland

来源：

CANCER CELL | 2014年 / 25卷 / 03期

基金：

英国惠康基金;

关键词：

OF-FUNCTION MUTANT; HUMAN-MALIGNANT GLIOMA; BREAST-CANCER; WILD-TYPE; GENE-EXPRESSION; FUNCTION PHENOTYPE; STROMAL FIBROBLASTS; ELEVATED EXPRESSION; FUNCTION MUTATIONS; ONCOGENIC FUNCTION;

D O I：

10.1016/j.ccr.2014.01.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

引用

页码：304 / 317

页数：14

共 171 条

[1] Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras [J].

Acin, Sergio ;

Li, Zhongyou ;

Mejia, Olga ;

Roop, Dennis R. ;

El-Naggar, Adel K. ;

Caulin, Carlos .

JOURNAL OF PATHOLOGY, 2011, 225 (04) :479-489

[2] p53 Status in Stromal Fibroblasts Modulates Tumor Growth in an SDF1-Dependent Manner [J].

Addadi, Yoseph ;

Moskovits, Neta ;

Granot, Dorit ;

Lozano, Guillermina ;

Carmi, Yaron ;

Apte, Ron N. ;

Neeman, Michal ;

Oren, Moshe .

CANCER RESEARCH, 2010, 70 (23) :9650-9658

[3] A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis [J].

Adorno, Maddalena ;

Cordenonsi, Michelangelo ;

Montagner, Marco ;

Dupont, Sirio ;

Wong, Christine ;

Hann, Byron ;

Solari, Aldo ;

Bobisse, Sara ;

Rondina, Maria Beatrice ;

Guzzardo, Vincenza ;

Parenti, Anna R. ;

Rosato, Antonio ;

Bicciato, Silvio ;

Balmain, Allan ;

Piccolo, Stefano .

CELL, 2009, 137 (01) :87-98

[4] Chromosome changes caused by alterations of p53 expression [J].

Agapova, LS ;

Ilyinskaya, GV ;

Turovets, NA ;

Ivanov, AV ;

Chumakov, PM ;

Kopnin, BP .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1996, 354 (01) :129-138

[5] Differential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells [J].

Ali, Amjad ;

Wang, Zhuo ;

Fu, Junjiang ;

Ji, Lei ;

Liu, Jiang ;

Li, Lei ;

Wang, Hui ;

Chen, Jiwu ;

Caulin, Carlos ;

Myers, Jeffrey N. ;

Zhang, Pei ;

Xiao, Jianru ;

Zhang, Bianhong ;

Li, Xiaotao .

NATURE COMMUNICATIONS, 2013, 4

[6] The gain of function of the p53 mutant Asp281Gly is dependent on its ability to form tetramers [J].

Atema, A ;

Chène, P .

CANCER LETTERS, 2002, 185 (01) :103-109

[7] Stromal fibroblasts in cancer initiation and progression [J].

Bhowmick, NA ;

Neilson, EG ;

Moses, HL .

NATURE, 2004, 432 (7015) :332-337

[8] Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy [J].

Blandino, G ;

Levine, AJ ;

Oren, M .

ONCOGENE, 1999, 18 (02) :477-485

[9] Targeted rescue of a destabilized mutant of p53 by an in silico screened drug [J].

Boeckler, Frank M. ;

Joerger, Andreas C. ;

Jaggi, Gaurav ;

Rutherford, Trevor J. ;

Veprintsev, Dmitry B. ;

Fersht, Alan R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (30) :10360-10365

[10] Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression [J].

Bossi, G ;

Lapi, E ;

Strano, S ;

Rinaldo, C ;

Blandino, G ;

Sacchi, A .

ONCOGENE, 2006, 25 (02) :304-309

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