Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells

被引：114

作者：

Kang, SS

Lee, JY

Choi, YK

Kim, GS

Han, BH ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea

[2] Seoul Natl Univ, Nat Prod Res Inst, Seoul 110460, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1016/j.bmcl.2004.02.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：2261 / 2264

页数：4

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