Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders

被引：41

作者：

Clauser, Sylvain ^{[1
,2
]}

Cramer-Borde, Elisabeth ^{[3
]}

机构：

[1] Univ Versailles, St Quentin en Yvelines, France

[2] Hop Ambroise Pare, Serv Hematol Immunol, AP HP, F-92104 Boulogne, France

[3] Inst Cochin, INSERM, U567, Dept Hematol, Paris, France

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2009年 / 35卷 / 02期

关键词：

Platelet; electron; microscopy; diagnosis; WISKOTT-ALDRICH-SYNDROME; BERNARD-SOULIER-SYNDROME; CHEDIAK-HIGASHI-SYNDROME; STORAGE POOL DEFICIENCY; UROKINASE PLASMINOGEN-ACTIVATOR; HERMANSKY-PUDLAK SYNDROME; PROLONGED BLEEDING TIMES; ALPHA-GRANULE DEFICIENCY; VON-WILLEBRAND-FACTOR; IB-IX COMPLEX;

D O I：

10.1055/s-0029-1220329

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The electron microscope has proved to be a useful tool to study and understand the biology of platelets and to classify many platelet disorders. After a technical overview, this article reviews syndromes originating from platelet organelle, cytoskeleton, and membrane defects for which electron microscopy plays a role in the diagnostic process, such as gray platelet syndrome, Paris-Trousseau syndrome, storage pool diseases, MYH9-related thrombocytopenias, or Wiskott-Aldrich syndrome. Particular focus is given to the ultrastructural aspect of platelets in these disorders.

引用

页码：213 / 223

页数：11

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