Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders

被引：41

作者：

Clauser, Sylvain ^{[1
,2
]}

Cramer-Borde, Elisabeth ^{[3
]}

机构：

[1] Univ Versailles, St Quentin en Yvelines, France

[2] Hop Ambroise Pare, Serv Hematol Immunol, AP HP, F-92104 Boulogne, France

[3] Inst Cochin, INSERM, U567, Dept Hematol, Paris, France

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2009年 / 35卷 / 02期

关键词：

Platelet; electron; microscopy; diagnosis; WISKOTT-ALDRICH-SYNDROME; BERNARD-SOULIER-SYNDROME; CHEDIAK-HIGASHI-SYNDROME; STORAGE POOL DEFICIENCY; UROKINASE PLASMINOGEN-ACTIVATOR; HERMANSKY-PUDLAK SYNDROME; PROLONGED BLEEDING TIMES; ALPHA-GRANULE DEFICIENCY; VON-WILLEBRAND-FACTOR; IB-IX COMPLEX;

D O I：

10.1055/s-0029-1220329

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The electron microscope has proved to be a useful tool to study and understand the biology of platelets and to classify many platelet disorders. After a technical overview, this article reviews syndromes originating from platelet organelle, cytoskeleton, and membrane defects for which electron microscopy plays a role in the diagnostic process, such as gray platelet syndrome, Paris-Trousseau syndrome, storage pool diseases, MYH9-related thrombocytopenias, or Wiskott-Aldrich syndrome. Particular focus is given to the ultrastructural aspect of platelets in these disorders.

引用

页码：213 / 223

页数：11

共 90 条

[21] BIOCHEMICAL-STUDIES OF 2 PATIENTS WITH THE GRAY PLATELET SYNDROME - SELECTIVE DEFICIENCY OF PLATELET ALPHA GRANULES [J].

GERRARD, JM ;

PHILLIPS, DR ;

RAO, GHR ;

PLOW, EF ;

WALZ, DA ;

ROSS, R ;

HARKER, LA ;

WHITE, JG .

JOURNAL OF CLINICAL INVESTIGATION, 1980, 66 (01) :102-109

[22] SEBASTIAN PLATELET SYNDROME - A NEW VARIANT OF HEREDITARY MACROTHROMBOCYTOPENIA WITH LEUKOCYTE INCLUSIONS [J].

GREINACHER, A ;

NIEUWENHUIS, HK ;

WHITE, JG .

BLUT, 1990, 61 (05) :282-288

[23] The 11q terminal deletion disorder: A prospective study of 110 cases [J].

Grossfeld, PD ;

Mattina, T ;

Lai, Z ;

Favier, R ;

Jones, KL ;

Cotter, F ;

Jones, C .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2004, 129A (01) :51-61

[24] WISKOTT-ALDRICH SYNDROME - QUALITATIVE PLATELET DEFECTS AND SHORT PLATELET SURVIVAL [J].

GROTTUM, KA ;

HOVIG, T ;

HOLMSEN, H ;

ABRAHAMSEN, AF ;

JEREMIC, M ;

SEIP, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1969, 17 (04) :373-+

[25] The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation [J].

Haddad, E ;

Cramer, E ;

Rivière, C ;

Rameau, P ;

Louache, F ;

Guichard, J ;

Nelson, DL ;

Fischer, A ;

Vainchenker, W ;

Debili, N .

BLOOD, 1999, 94 (02) :509-518

[26]

HARDISTY RM, 1967, LANCET, V1, P983

[27]

Hayward CPM, 1997, BLOOD, V89, P1243, DOI 10.1182/blood.V89.4.1243

[28] An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect [J].

Hayward, CPM ;

Rivard, GE ;

Kane, WH ;

Drouin, J ;

Zheng, SL ;

Moore, JC ;

Kelton, JG .

BLOOD, 1996, 87 (12) :4967-4978

[29] MULTIMERIN IS FOUND IN THE ALPHA-GRANULES OF RESTING PLATELETS AND IS SYNTHESIZED BY A MEGAKARYOCYTIC CELL-LINE [J].

HAYWARD, CPM ;

BAINTON, DF ;

SMITH, JW ;

HORSEWOOD, P ;

STEAD, RH ;

PODOR, TJ ;

WARKENTIN, TE ;

KELTON, JG .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2630-2639

[30]

HEGGLIN R, 1945, HELVET MED ACTA A, V4, P439

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