Hepatitis E in pregnancy

被引:218
作者
Kumar, A
Beniwal, M
Kar, P
Sharma, JB
Murthy, NS
机构
[1] Maulana Azad Med Coll, Dept Obstet & Gynaecol, New Delhi, India
[2] Maulana Azad Med Coll, Dept Med, New Delhi, India
[3] Maulana Azad Med Coll, Indian Council Med Res, Dept Biostat, New Delhi, India
关键词
hepatitis; pregnancy; third trimester; hepatitis E virus; vertical transmission;
D O I
10.1016/j.ijgo.2003.11.018
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: To study the spectrum and the clinical and biochemical course of viral hepatitis E during pregnancy. Methods: In this prospective study, sera of 62 pregnant women having jaundice in the third trimester of pregnancy were analyzed for markers of hepatitis A, B, C and E viruses. The cord blood samples of hepatitis E virus (HEV)-positive pregnant women at the time of delivery were tested for IgM anti-HEV antibodies by enzyme-linked immunosorbent assay and HEV-RNA by reverse transcriptase polymerase chain reaction. Results: Of the 62 patients, 45.2% had HEV infection and nine developed fulminant hepatic failure (FHF). Eighty-one percent of FHF cases and 37.25% of acute viral hepatitis cases were caused by HEV. Approximately two-thirds of the pregnant women with HEV infection had preterm deliveries. The mortality rate among the HEV-positive pregnant women was 26.9%. Vertical transmission was observed in 33.3% of cases. Conclusions: One-third of the pregnant women with HEY infection had a severe form of hepatitis in the third trimester of pregnancy, i.e. FHF. Hepatitis E in pregnancy is associated with high rates of preterm labor and mortality. (C) 2003 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:240 / 244
页数:5
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