Restricted expression of ETn-related sequences during post-implantation mouse development

被引：22

作者：

Loebel, DAF ^{[1
]}

Tsoi, B ^{[1
]}

Wong, N ^{[1
]}

O'Rourke, MP ^{[1
]}

Tam, PPL ^{[1
]}

机构：

[1] Childrens Med Res Inst, Embryol Unit, Wentworthville, NSW 2145, Australia

来源：

GENE EXPRESSION PATTERNS | 2004年 / 4卷 / 04期

基金：

英国医学研究理事会;

关键词：

twist; early transposon; endogenous provirus elements; transposable element; mouse; gastrulation; organogenesis;

D O I：

10.1016/j.modgep.2003.12.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a screen for potential targets of regulation by TWIST in mouse embryos we isolated a fragment with homology to type 11 early transposon (ETn) and type D endogenous provirus (MusD) elements. Whole-mount in situ hybridization to E7.5-E13.5 mouse embryos reveals a tissue- and stage-specific expression pattern that contrasts with the previously reported lack of expression of ETn elements in mouse embryos beyond late gastrulation. Transcripts were detected in the epiblast at E7.5 and in the neural tube from E8.5 to E10.5. Later expression is predominantly confined to the mesodermal tissues of cramofacial structures, limb buds and somites. The tissue specificity of expression suggests tight regulation of the activity of this early transposon element during embryogenesis. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：467 / 471

页数：5

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