The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat

被引：32

作者：

Cox, ML ^{[1
]}

Welch, SP ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 493卷 / 1-3期

关键词：

arthritis; Delta(9)-THC; dynorphin A;

D O I：

10.1016/j.ejphar.2004.04.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta(9)-tetrahydrocannabinol (Delta(9)-THC)-induced antinociception in Freund's adjuvant-induced arthritic and nonarthritic rats. The paw-pressure test was used to assess the antinociceptive effects of Delta(9)-THC versus those of morphine, and opioid and cannabinoid receptor-selective antagonists were used to characterize the involved receptors. Cerebrospinal fluid was collected after Delta(9)-THC injection (i.p.) for the measurement of endogenous opioid peptides. Our results indicate that morphine or Delta(9)-THC is equally potent and efficacious in both nonarthritic and arthritic rats. Delta(9)-THC-induced antinociception is attenuated by the K opioid receptor antagonist, nor-binaltorphimine, in arthritic rats only. Delta(9)-THC induces increased immunoreactive dynorphin A (idyn A) levels in nonarthritic rats while decreasing idyn A in arthritic rats. We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta(9)-THC induces antinociception by decreasing idyn A release. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：65 / 74

页数：10

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