A formal asyrnmetric synthesis of both enantiomers of the Erythrina alkaloid 3-demethoxyerythratidinone

被引:41
作者
Allin, SM [1 ]
Streetley, GB
Slater, M
James, SL
Martin, WP
机构
[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England
[2] BioFocus Discovery Ltd, Saffron Walden CB10 1XL, Essex, England
[3] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England
关键词
D O I
10.1016/j.tetlet.2004.05.060
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A formal asymmetric synthesis of both enantiomers of the Erythrina alkaloid 3-demethoxyerythiatidinone is reported through the application of a highly functionalised lactam template as an N-acyliminium precursor. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5493 / 5496
页数:4
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