Harvesting the mouse genome

被引:3
作者
Botcherby, M [1 ]
机构
[1] MRC, HGMP Resource Ctr, Cambridge CB10 1SB, England
来源
COMPARATIVE AND FUNCTIONAL GENOMICS | 2002年 / 3卷 / 04期
关键词
mouse; sequencing; whole genome shotgun; ARACHNE; cDNA;
D O I
10.1002/cfg.198
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The sequencing of the black 6 mouse (strain C57Bl/6) has reached an important juncture. The BAC fingerprint map is almost complete, the BACs have been end-sequenced and a seven-fold coverage whole-genome shotgun has been assembled. Now the BAC-by-BAC sequencing phase is under way and in-depth comparative analysis can be carried out on regions that have been the subject of targeted sequencing. This paper reviews the progress so far and looks forward to the promises of finished sequence. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码:319 / 324
页数:6
相关论文
共 5 条
[1]  
Batzoglou S, 2002, GENOME RES, V12, P177, DOI 10.1101/gr.208902
[2]   New 3′ elements control Pax6 expression in the developing pretecturn, neural retina and olfactory region [J].
Griffin, C ;
Kleinjan, DA ;
Doe, B ;
van Heyningen, V .
MECHANISMS OF DEVELOPMENT, 2002, 112 (1-2) :89-100
[3]   Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance [J].
Kleinjan, DA ;
Seawright, A ;
Elgar, G ;
van Heyningen, V .
MAMMALIAN GENOME, 2002, 13 (02) :102-107
[4]   Complete sequencing of the Fugu WAGR region from WT1 to PAX6:: Dramatic compaction and conservation of synteny with human chromosome 11p13 [J].
Miles, C ;
Elgar, G ;
Coles, E ;
Kleinjan, DJ ;
van Heyningen, V ;
Hastie, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13068-13072
[5]   PipMaker - A Web server for aligning two genomic DNA sequences [J].
Schwartz, S ;
Zhang, Z ;
Frazer, KA ;
Smit, A ;
Riemer, C ;
Bouck, J ;
Gibbs, R ;
Hardison, R ;
Miller, W .
GENOME RESEARCH, 2000, 10 (04) :577-586