Characterization of the regulatory region of the human testis-specific form of the pyruvate dehydrogenase α-subunit (PDHA-2) gene

被引：16

作者：

Datta, U

Wexler, ID

Kerr, DS

Raz, I

Patel, MS

机构：

[1] SUNY Buffalo, Sch Med & Biomed Sci, Dept Biochem, Buffalo, NY 14214 USA

[2] Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA

[3] Hadassah Univ, Dept Med, Med Ctr, Jerusalem, Israel

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1447卷 / 2-3期

关键词：

human pyruvate dehydrogenase alpha-subunit gene (PDHA-2); promoter sequence; gene regulation;

D O I：

10.1016/S0167-4781(99)00158-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-subunit of human pyruvate dehydrogenase (E-1) is encoded by two separate genes. The gene located on chromosome X (PDHA-1) is expressed in somatic tissues, whereas the second gene (PDHA-2), located on chromosome 4, is expressed only in post-meiotic spermatogenic cells. A genomic fragment harboring the human gene encoding PDHA-2 has been isolated and approximately 800 nucleotides of the promoter region have been characterized. Functional studies of the promoter indicate the presence of both enhancer and repressor elements that are common to other genes that are only expressed in mature sperm. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：236 / 243

页数：8

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