Flavonoid-induced autophagy in hormone sensitive breast cancer cells

被引：19

作者：

Brunelli, Elisa

Pinton, Giulia

Bellini, Paolo

Minassi, Alberto

Appendino, Giovanni

Moro, Laura ^{[1
]}

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

来源：

FITOTERAPIA | 2009年 / 80卷 / 06期

关键词：

8-Prenylapigenin; 8-Prenylnaringenin; Isocannflavin B; Breast cancer cells; Cell signalling; Autophagy; ESTROGEN-RECEPTOR; KINASE INHIBITOR; 8-PRENYLNARINGENIN; PRENYLFLAVONOIDS; APOPTOSIS; GROWTH;

D O I：

10.1016/j.fitote.2009.04.002

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21(CiP1) expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：327 / 332

页数：6

共 19 条

[1]

Signaling regulation of genomic and nongenomic functions of estrogen receptors [J].

Acconcia, Filippo ;

Kumar, Rakesh .

CANCER LETTERS, 2006, 238 (01) :1-14

[2]

BIEDERBICK A, 1995, EUR J CELL BIOL, V66, P3

[3]

8-Prenylnaringenin, inhibits estrogen receptor-α mediated cell growth and induces apoptosis in MCF-7 breast cancer cells [J].

Brunelli, Elisa ;

Minassi, Alberto ;

Appendino, Giovanni ;

Moro, Laura .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 107 (3-5) :140-148

[4]

8-Prenylnaringenin inhibits epidermal growth factor-induced MCF-7 breast cancer cell proliferation by targeting phosphatidylinositol-3-OH kinase activity [J].

Brunelli, Elisa ;

Pinton, Giulia ;

Chianale, Federica ;

Graziani, Andrea ;

Appendino, Giovanni ;

Moro, Laura .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2009, 113 (3-5) :163-170

[5]

PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [J].

Castoria, G ;

Migliaccio, A ;

Bilancio, A ;

Di Domenico, M ;

de Falco, A ;

Lombardi, M ;

Fiorentino, R ;

Varricchio, L ;

Barone, MV ;

Auricchio, F .

EMBO JOURNAL, 2001, 20 (21) :6050-6059

[6]

Synthesis of four natural prenylflavonoids and their estrogen-like activities [J].

Dong, Xiaowu ;

Fan, Yongjian ;

Yu, Lingjun ;

Hu, Yongzhou .

ARCHIV DER PHARMAZIE, 2007, 340 (07) :372-376

[7]

Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy [J].

Fujiwara, Keishi ;

Daido, Shigeru ;

Yamamoto, Akitsugu ;

Kobayashi, Ryuji ;

Yokoyama, Tomohisa ;

Aoki, Hiroshi ;

Iwado, Eiji ;

Shinojima, Naoki ;

Kondo, Yasuko ;

Kondo, Seiji .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (01) :388-397

[8]

Prenylflavonoids: A new class of non-steroidal phytoestrogen (part 1). Isolation of 8-lsopentenylnaringenin and an initial study on its structure-activity relationship [J].

Kitaoka, M ;

Kadokawa, H ;

Sugano, M ;

Ichikawa, K ;

Taki, M ;

Takaishi, S ;

Iijima, Y ;

Tsutsumi, S ;

Boriboon, M ;

Akiyama, T .

PLANTA MEDICA, 1998, 64 (06) :511-515

[9]

Marino Maria, 2005, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V5, P305, DOI 10.2174/1568008054863763

[10]

Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells [J].

Matsumura, A ;

Ghosh, A ;

Pope, GS ;

Darbre, PD .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2005, 94 (05) :431-443

← 1 2 →