MnSOD expression is increased in metastatic gastric cancer

被引:112
作者
Malafa, M
Margenthaler, J
Webb, B
Neitzel, L
Christophersen, M
机构
[1] So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA
[2] Mem Med Ctr, Dept Pathol, Springfield, IL 62781 USA
关键词
gastric cancer; superoxide dismutase; metastases; immunohistochemistry;
D O I
10.1006/jsre.1999.5773
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. Manganese superoxide dismutase (MnSOD) catalyzes the scavenging of superoxide radicals in order to protect cells from the damage caused by reactive oxygen species. Previous studies implicate MnSOD in cancer progression, but its role in gastric cancer metastasis is poorly understood. Materials and methods, To determine whether MnSOD expression correlates with gastric cancer metastasis, we compared immunostaining for MnSOD in the primary tumors of gastric cancer patients with (n = 15) and without (n = 9) nodal metastases, These patients were matched for risk factors associated with gastric cancer metastasis, such as tumor site, depth, and grade. MnSOD expression was scored positive (increased) if MnSOD staining of tumor cells was more intense than MnSOD staining in corresponding normal gastric epithelial cells. Statistical analyses were via Xe test and Fisher's exact test. Results, MnSOD expression was increased in 14 of the 15 (93%) metastatic tumors, compared to only 4 of the 9 (44%) nonmetastatic tumors (P = 0.015). There was no significant difference in staining when the two groups were compared based on tumor grade (P = 0.70) or depth of tumor cell invasion (T stage) (P = 0.22), Conclusions. MnSOD expression is upregulated in the primary tumors of gastric cancer patients with lymph node metastases, This finding supports an involvement of MnSOD and possibly the reactive oxygen status of the gastric tumor microenvironment in gastric cancer metastasis. (C) 2000 Academic Press.
引用
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页码:130 / 134
页数:5
相关论文
共 15 条
[1]  
Alexander H. Richard, 1997, P1021
[2]  
Arivazhagan K, 1997, CELL BIOCHEM FUNCT, V15, P15
[3]  
BENO I, 1993, NEOPLASMA, V40, P315
[4]   INCREASED MANGANESE SUPEROXIDE-DISMUTASE EXPRESSION SUPPRESSES THE MALIGNANT PHENOTYPE OF HUMAN-MELANOMA CELLS [J].
CHURCH, SL ;
GRANT, JW ;
RIDNOUR, LA ;
OBERLEY, LW ;
SWANSON, PE ;
MELTZER, PS ;
TRENT, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :3113-3117
[5]  
GRACE H, 1988, SCIENCE, V242, P941
[6]   OVEREXPRESSION OF MITOCHONDRIAL MANGANESE SUPEROXIDE-DISMUTASE PROMOTES THE SURVIVAL OF TUMOR-CELLS EXPOSED TO INTERLEUKIN-1, TUMOR-NECROSIS-FACTOR, SELECTED ANTICANCER DRUGS, AND IONIZING-RADIATION [J].
HIROSE, K ;
LONGO, DL ;
OPPENHEIM, JJ ;
MATSUSHIMA, K .
FASEB JOURNAL, 1993, 7 (02) :361-368
[7]   Enhanced expression of manganese superoxide dismutase mRNA and increased TNF alpha mRNA expression by gastric mucosa in gastric cancer [J].
Izutani, R ;
Katoh, M ;
Asano, S ;
Ohyanagi, H ;
Hirose, K .
WORLD JOURNAL OF SURGERY, 1996, 20 (02) :228-233
[8]   Expression of manganese superoxide dismutase in esophageal and gastric cancers [J].
Izutani, R ;
Asano, S ;
Imano, M ;
Kuroda, D ;
Kato, M ;
Ohyanagi, H .
JOURNAL OF GASTROENTEROLOGY, 1998, 33 (06) :816-822
[9]   INDUCTION OF MITOCHONDRIAL MANGANESE SUPEROXIDE-DISMUTASE BY INTERLEUKIN-1 [J].
MASUDA, A ;
LONGO, DL ;
KOBAYASHI, Y ;
APPELLA, E ;
OPPENHEIM, JJ ;
MATSUSHIMA, K .
FASEB JOURNAL, 1988, 2 (15) :3087-3091
[10]  
OBERLEY LW, 1979, CANCER RES, V39, P1141