Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

被引：205

作者：

Herold, Susanne ^{[1
]}

Gabrielli, Nieves M. ^{[1
]}

Vadasz, Istvan ^{[1
]}

机构：

[1] Univ Giessen, Univ Giessen & Marburg Lung Ctr, Dept Internal Med, D-35392 Giessen, Germany

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2013年 / 305卷 / 10期

关键词：

alveolar-capillary barrier dysfunction; molecular mechanism; pharmacological and cell-based therapy; pulmonary edema; zaacute lung injury/acute respiratory distress syndrome; RESPIRATORY-DISTRESS-SYNDROME; COLONY-STIMULATING FACTOR; MESENCHYMAL STEM-CELLS; GLYCATION END-PRODUCTS; PROVIDING PERMISSIVE HYPERCAPNIA; TRANSEPITHELIAL LIQUID TRANSPORT; NEUTROPHIL EXTRACELLULAR TRAPS; SODIUM-CHANNEL ACTIVITY; INNATE IMMUNE-RESPONSE; REGULATORY T-CELLS;

D O I：

10.1152/ajplung.00232.2013

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

In this review we summarize recent major advances in our understanding on the molecular mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary barrier dysfunction, highlighting the role of immune cells, inflammatory and noninflammatory signaling events, mechanical noxae, and the affected cellular and molecular entities and functions. Furthermore, we address novel aspects of resolution and repair of ALI, as well as putative candidates for treatment of ALI, including pharmacological and cellular therapeutic means.

引用

收藏

页码：L665 / L681

页数：17

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