Fabrication of nonporous and porous cationic PLGA microspheres

被引：9

作者：

Fang, Kun ^{[1
,2
]}

Yang, Fang ^{[1
]}

Zhang, Qiying ^{[1
]}

Zhang, Tianzhu ^{[1
]}

Gu, Ning ^{[1
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Jiangsu, Peoples R China

[2] State Key Lab Pharmaceut Biotechnol, Nanjing 210096, Jiangsu, Peoples R China

来源：

MATERIALS LETTERS | 2014年 / 117卷

关键词：

Polymeric composites; Microstructure; Porous materials; Drug delivery; Macromolecule; DRUG-DELIVERY; REGENERATIVE MEDICINE; SUSTAINED-RELEASE; MICROPARTICLES; PARTICLES; LUNG;

D O I：

10.1016/j.matlet.2013.11.101

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

A modified water-oil-water double emulsion solvent evaporation method was used to prepare cationic poly (lactic-co-glycolic acid) microspheres. Polyethyleneimine in external water phase was used to stabilize the microspheres and ammonium bicarbonate in internal aqueous phase was adopted to facilitate the formation of pores. It is found that the microspheres with or without pores could be manipulated by easily adjusting the polyethyleneimine concentration. In order to understand the drug delivery potential of the porous microspheres, the model macromolecule agent, fluorescein isothiocyanate-dextran was used. The results show that the porous microspheres obtained by emulsion processing have higher absorption capability compared with non-porous ones. Therefore, the as-obtained porous microspheres could be the suitable platforms for the delivery of bioactive agents. (C) 2013 Elsevier B.V. All rights reserved

引用

页码：86 / 89

页数：4

共 19 条

[1]

PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect [J].