Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices

被引：237

作者：

Gultepe, Evin ^{[1
,2
]}

Nagesha, Dattatri ^{[1
,2
]}

Sridhar, Srinivas ^{[1
,2
]}

Amiji, Mansoor ^{[3
]}

机构：

[1] Northeastern Univ, Elect Mat Res Inst, Boston, MA 02115 USA

[2] Northeastern Univ, Dept Phys, Boston, MA 02115 USA

[3] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 03期

关键词：

Drug release; Alumina; Titania; Porous silicon; Biocompatibility; Implant coatings; ANODIC ALUMINUM-OXIDE; POROUS SILICON; SURFACE MODIFICATION; MESOPOROUS SILICON; CONTROLLED-RELEASE; BONE; ARRAYS; BIOCOMPATIBILITY; SYSTEM; OSTEOBLASTS;

D O I：

10.1016/j.addr.2009.11.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The characteristics of nanoporous inorganic coatings on implants or on implantable devices are reviewed. The commonly used nanoporous materials, such as aluminum oxide (Al2O3), titanium oxide (TiO2) and porous silicon are highlighted with illustrative examples. The critical issues for sustained release systems are examined and the elution profiles of nanoporous coatings are discussed. The available data shows that these systems can be used effectively for sustained release applications. They satisfy the basic biocompatibility tests, meet the requirements of drug loading and sustained release profiles extending to several weeks and also are compatible with current implant technologies. Nanoporous inorganic coatings are well suited to provide improved efficacy and integration of implants in a variety of therapeutic situations. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：305 / 315

页数：11

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