Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders

被引：18

作者：

Goriely, S. ^{[1
]}

Cavoy, R. ^{[1
]}

Goldman, M. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Inst Med Immunol, B-6041 Charleroi, Belgium

来源：

ALLERGY | 2009年 / 64卷 / 05期

关键词：

autoimmunity; inteferon; interleukin-27; regulatory T cells; T-helper; 17; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; PLASMACYTOID DENDRITIC CELLS; REGULATORY T-CELLS; COLLAGEN-INDUCED ARTHRITIS; HUMAN TH17 CELLS; CUTTING EDGE; LUPUS-ERYTHEMATOSUS; IFN-BETA; EXPERIMENTAL COLITIS;

D O I：

10.1111/j.1398-9995.2009.02039.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Cytokines produced by antigen-presenting cells govern the fate of helper T-cell responses. Herein, we review the impact of interleukin (IL)-23 and IL-27 on the outcome of T-helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T-cell-mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL-12 family members.

引用

页码：702 / 709

页数：8

共 99 条

[1]

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2]

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 [J].

Amadi-Obi, Ahjoku ;

Yu, Cheng-Rong ;

Liu, Xuebin ;

Mahdi, Rashid M. ;

Clarke, Grace Levy ;

Nussenblatt, Robert B. ;

Gery, Igal ;

Lee, Yun Sang ;

Egwuagu, Charles E. .

NATURE MEDICINE, 2007, 13 (06) :711-718

[3]

Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[4]

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells [J].

Awasthi, Amit ;

Carrier, Yijun ;

Peron, Jean P. S. ;

Bettelli, Estelle ;

Kamanaka, Masahito ;

Flavell, Richard A. ;

Kuchroo, Vijay K. ;

Oukka, Mohamed ;

Weiner, Howard L. .

NATURE IMMUNOLOGY, 2007, 8 (12) :1380-1389

[5]

Interferons as pathogenic effectors in autoimmunity [J].

Baccala, R ;

Kono, DH ;

Theofilopoulos, AN .

IMMUNOLOGICAL REVIEWS, 2005, 204 :9-26

[6]

Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis [J].

Bailey-Bucktrout, Samantha L. ;

Caulkins, Sarah C. ;

Goings, Gwendolyn ;

Fischer, Jens A. A. ;

Dzionek, Andrzej ;

Miller, Stephen D. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (10) :6457-6461

[7]

Type I interferon in systemic lupus erythematosus and other autoimmune diseases [J].

Banchereau, Jacques ;

Pascual, Virginia .

IMMUNITY, 2006, 25 (03) :383-392

[8]

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells [J].

Batten, Marcel ;

Kljavin, Noelyn M. ;

Li, Ji ;

Walter, Michael J. ;

de Sauvage, Frederic J. ;

Ghilardi, Nico .

JOURNAL OF IMMUNOLOGY, 2008, 180 (05) :2752-2756

[9]

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells [J].

Batten, Marcel ;

Li, Ji ;

Yi, Sothy ;

Kljavin, Noelyn M. ;

Danilenko, Dimitry M. ;

Lucas, Sophie ;

Lee, James ;

de Sauvage, Frederic J. ;

Ghilardi, Nico .

NATURE IMMUNOLOGY, 2006, 7 (09) :929-936

[10]

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition [J].

Bauer, S ;

Kirschning, CJ ;

Häcker, H ;

Redecke, V ;

Hausmann, S ;

Akira, S ;

Wagner, H ;

Lipford, GB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9237-9242

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