Cognitive reserve

被引:2172
作者
Stern, Yaakov [1 ,2 ]
机构
[1] Columbia Univ, Cognit Neurosci Div, Taub Inst, Coll Phys & Surg,Dept Neurol, New York, NY 10027 USA
[2] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY 10027 USA
关键词
Aging; Dementia; Epidemiolgy; FMRI; Neuroimaging; AGE-RELATED-CHANGES; EVENT-RELATED FMRI; ALZHEIMERS-DISEASE; LEISURE ACTIVITY; METABOLIC-RATES; OLDER PERSONS; HEALTHY-YOUNG; RISK-FACTORS; BRAIN SIZE; BLOOD-FLOW;
D O I
10.1016/j.neuropsychologia.2009.03.004
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The concept of reserve has been proposed to account for the disjunction between the degree of brain damage and its clinical outcome. This paper attempts to produce a coherent theoretical account the reserve in general and of cognitive reserve in particular. It reviews epidemiologic data supporting the concept of cognitive reserve, with a particular focus of its implications for aging and dementia. It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2015 / 2028
页数:14
相关论文
共 70 条
[61]   Rate of memory decline in AD is related to education and occupation - Cognitive reserve? [J].
Stern, Y ;
Albert, S ;
Tang, MX ;
Tsai, WY .
NEUROLOGY, 1999, 53 (09) :1942-1947
[62]  
STERN Y, 2007, COGNITIVE RESERVE TH, P251
[63]   A common neural network for cognitive reserve in verbal and object working memory in young but not old [J].
Stern, Yaakov ;
Zarahn, Eric ;
Habeck, Christian ;
Holtzer, Roee ;
Rakitin, Brian C. ;
Kumar, Arjun ;
Flynn, Joseph ;
Steffener, Jason ;
Brown, Truman .
CEREBRAL CORTEX, 2008, 18 (04) :959-967
[64]  
Valentin J, 2005, Ann ICRP, V35, P1
[65]   Exercise enhances learning and hippocampal neurogenesis in aged mice [J].
van Praag, H ;
Shubert, T ;
Zhao, CM ;
Gage, FH .
JOURNAL OF NEUROSCIENCE, 2005, 25 (38) :8680-8685
[66]   Neuroimaging studies of shifting attention: a meta-analysis [J].
Wager, TD ;
Jonides, J ;
Reading, S .
NEUROIMAGE, 2004, 22 (04) :1679-1693
[67]   Neuroimaging studies of working memory: A meta-analysis [J].
Wager, Tor D. ;
Smith, Edward E. .
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 2003, 3 (04) :255-274
[68]   INVIVO BRAIN SIZE AND INTELLIGENCE [J].
WILLERMAN, L ;
SCHULTZ, R ;
RUTLEDGE, JN ;
BIGLER, ED .
INTELLIGENCE, 1991, 15 (02) :223-228
[69]   Characterizing the response of PET and fMRI data using multivariate linear models [J].
Worsley, KJ ;
Poline, JB ;
Friston, KJ ;
Evans, AC .
NEUROIMAGE, 1997, 6 (04) :305-319
[70]   Age-related changes in brain activation during a delayed item recognition task [J].
Zarahn, Eric ;
Rakitin, Brian ;
Abela, Diane ;
Flynn, Joseph ;
Stern, Yaakov .
NEUROBIOLOGY OF AGING, 2007, 28 (05) :784-798