Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

被引：118

作者：

Lipsky, PE

Brooks, P

Crofford, LJ

DuBois, R

Graham, D

Simon, LS

van de Putte, LBA

Abramson, SB

机构：

[1] Univ Texas, SW Med Ctr, Div Rheumat Dis, Arthritis Res Ctr, Dallas, TX 75235 USA

[2] Univ Queensland, Brisbane, Qld, Australia

[3] Univ Michigan, Ctr Med, Ann Arbor, MI 48109 USA

[4] Vanderbilt Univ, Ctr Med, Nashville, TN 37232 USA

[5] Vet Affairs Med Ctr, Houston, TX 77030 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

[7] Univ Nijmegen Hosp, NL-6500 HB Nijmegen, Netherlands

[8] NYU, Sch Med, New York, NY USA

来源：

ARCHIVES OF INTERNAL MEDICINE | 2000年 / 160卷 / 07期

关键词：

D O I：

10.1001/archinte.160.7.913

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

引用

页码：913 / 920

页数：8

共 119 条

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