Characterization of echovirus 25 (ECV 25) in the VP1/2A gene junction region -: Brief Report

被引：11

作者：

Künkel, U ^{[1
]}

Schreier, E ^{[1
]}

机构：

[1] Robert Koch Inst, D-13353 Berlin, Germany

来源：

ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 11期

关键词：

D O I：

10.1007/s007050050640

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetic relationships among echovirus type 25 (ECV 25) isolates associated with aseptic meningitis in Germany 1997/98 and a 40-year-old ECV 25 prototype strain were investigated using RT-PCR and direct sequencing the VP1/2A gene junction region. Sequences were compared to each other and to nonpolio enterovirus representatives (phylogenetic analysis). The analysis indicated that the sequences of recent isolates have drifted over time distinctly away from the prototype strain sequence. Genetic drift may change biological features of isolates possibly leading to new antigenic variants.

引用

页码：2253 / 2258

页数：6

共 9 条

[1] SEQUENCE COMPARISON OF ECHOVIRUS TYPE-30 ISOLATES TO OTHER ENTEROVIRUSES IN THE 5'NONCODING REGION [J].