Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells

被引：202

作者：

Sato, M

Kimura, TU

Kurokawa, K

Fujita, Y

Abe, K

Masuhara, M

Yasunaga, T

Ryo, A

Yamamoto, M

Nakano, T

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Mol Cell Biol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Genome Informat Res Ctr, Dept Human Genome Res, Suita, Osaka 5650871, Japan

[3] Natl Def Med Coll, Dept Biochem, Tokorozawa, Saitama 3598513, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 113卷 / 01期

基金：

日本学术振兴会;

关键词：

primordial germ cells; embryonic stem cells; cDNA analysis; Oct-3/4; tissue non-specific alkaline phosphatase; pre-implantation; oocytes; oogenesis;

D O I：

10.1016/S0925-4773(02)00002-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene. PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：91 / 94

页数：4

共 9 条

[1] Purification of primordial germ cells from TNAP(beta-geo) mouse embryos using FACS-gal [J].