Optimization of cationic lipid mediated gene transfer:: Structure-function, physico-chemical, and cellular studies

被引：12

作者：

Carrière, M

Tranchant, I

Niore, PA

Byk, G

Mignet, N

Escriou, V

Scherman, D

Herscovici, J

机构：

[1] ENSCP, CNRS, UMR 7001, Lab Chim Bioorgan & Biotehnol Mol & Cellulaire, F-75013 Paris, France

[2] CRVA Aventis Pharma, F-94403 Vitry Sur Seine, France

来源：

JOURNAL OF LIPOSOME RESEARCH | 2002年 / 12卷 / 1-2期

关键词：

cationic lipids; gene transfer; physico-chemistry;

D O I：

10.1081/LPR-120004781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rationale design aimed at the enhancement of cationic lipid mediated gene transfer is discussed. These improvements are based on the straight evaluation of the structure-activity relationship and on the introduction of new structures. Much attention have been given to the supramolecular structures of the lipid/DNA complexes, to the effect of serum on gene transfer and to the intracellular trafficking of the lipoplexes. Finally new avenue using reducible cationic lipids has been discussed.

引用

页码：95 / 106

页数：12