Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGluR1 mutant mice

被引:50
作者
Levenes, C
Daniel, H
Jaillard, D
Conquet, F
Crepel, F
机构
[1] CNRS,NEUROBIOL LAB,F-91405 ORSAY,FRANCE
[2] UNIV PARIS 11,F-91405 ORSAY,FRANCE
[3] GLAXO INST MOL BIOL,CH-1228 PLAN LES OUATES,GENEVA,SWITZERLAND
关键词
cerebellar Purkinje cells; climbing fibres; knock-out mice; multiple innervation;
D O I
10.1097/00001756-199701200-00038
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
RECENT reports have suggested the existence of a causal relationship between impaired regression of multiple climbing fibre innervation and impaired motor coordination in protein kinase C gamma subunit (PKC gamma) mutant mice. In the present patch-clamp study, performed in thin cerebellar slices prepared from adult mutant mice deficient in metabotropic glutamate receptors of the mGluR1 subtype, only 15% of Purkinje cells remained multiply innervated by climbing fibres, but motor coordination was largely impaired in these animals. The present results do not preclude the existence of a causal relationship between impairement of regression of multiple innervation during development and improper motor coordination in the adult.
引用
收藏
页码:571 / 574
页数:4
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