Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes

被引：32

作者：

Cunnington, M. S. ^{[1
]}

Mayosi, B. M. ^{[2
]}

Hall, D. H. ^{[1
]}

Avery, P. J. ^{[3
]}

Farrall, M. ^{[4
]}

Vickers, M. A. ^{[5
]}

Watkins, H. ^{[4
]}

Keavney, B. ^{[1
]}

机构：

[1] Univ Newcastle, Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[2] Univ Cape Town, Dept Med, Cape Town, South Africa

[3] Univ Newcastle, Sch Math & Stat, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[4] Univ Oxford, Dept Cardiovasc Med, Oxford, England

[5] Univ Aberdeen, Dept Med & Therapeut, Aberdeen, Scotland

来源：

ATHEROSCLEROSIS | 2009年 / 203卷 / 01期

基金：

英国惠康基金;

关键词：

Atherosclerosis; Carotid arteries; Stroke; Genetics; CARDIOVASCULAR-DISEASE; INTERLEUKIN-6; METAANALYSIS; EVENTS; FAMILY;

D O I：

10.1016/j.atherosclerosis.2008.06.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. We investigated association of reported CAD risk variants with CIMT, and with other intermediate phenotypes that may implicate causative pathways. Methods: We Studied 1425 members of 248 British Caucasian families ascertained through a hypertensive proband. We genotyped CAD risk SNPs on chromosomes 9 (rs 1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. Merlin software was used for faintly-based association testing. Results: No significant association was found between genotype at any SNP and CIMT in 846 individuals with acceptable measurements. Nor were SNPs significantly associated with blood pressure, obesity, cholesterol, CRP, interleukin-6, TNF-alpha, or leptin. Conclusions: These novel CAD variants are not associated with CIMT and do not appear to mediate the risk of atherothrombosis through known risk factors. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

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