Complement anaphylatoxin C3a and C5a formation in premature children with respiratory distress

被引：10

作者：

Enskog, A

Bengtsson, A

Bengtson, JP

Heideman, M

Andreasson, S

Larsson, L

机构：

[1] SAHLGRENS UNIV HOSP,DEPT ANAESTHESIOL & INTENS CARE,S-41345 GOTHENBURG,SWEDEN

[2] BORAS HOSP,DEPT SURG,BORAS,SWEDEN

[3] OSTRA HOSP,CHILDRENS HOSP,DEPT PAEDIAT ANAESTHESIA & INTENS CARE,S-41685 GOTHENBURG,SWEDEN

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1996年 / 155卷 / 01期

关键词：

anaphylatoxin; complement; respiratory distress; preterm children;

D O I：

10.1007/BF02309855

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Premature children (n = 25) with respiratory distress (RD) were studied regarding complement activation and formation of the anaphylatoxins C3a and C5a. Blood samples were drawn on admission to the paediatric intensive care unit. In 18 of the patients RD was accompanied by other perinatal complications like pneumothorax or intracerebral haemorrhages. Seven of the premature children had RD without such complications. Preterm children with RD and with peri- and postnatal complications such as pneumothorax or intracerebral haemorrhage had increased concentrations in plasma of the anaphylatoxins preterm children with RD without these complications. There was a positive correlation between the plasma C3a and C5a concentrations in the preterm children. Conclusion The present study indicates that isolated RD will appear without signs of complement activation and that complications like pneumothorax or intracerebral haemorrhages are associated with release of the anaphylatoxins C3a and C5a.

引用

页码：41 / 45

页数：5