Exercise Improves Cognitive Impairment and Dopamine Metabolism in MPTP-Treated Mice

被引：30

作者：

Aguiar, Aderbal S., Jr. ^{[1
,2
]}

Lopes, Samantha C. ^{[1
]}

Tristo, Fabrine S. M. ^{[3
]}

Rial, Daniel ^{[1
]}

de Oliveira, Gisele ^{[4
]}

da Cunha, Claudio ^{[4
]}

Raisman-Vozari, Rita ^{[3
]}

Prediger, Rui D. ^{[2
]}

机构：

[1] Univ Fed Santa Catarina, Dept Farmacol, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Bioquim, Ctr Cincias Biol, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Paris 06, INSERM UMR 975, Ctr Rech Inst Cerveau & Moelle Epiniere, CNRS UMR 7225, F-75651 Paris, France

[4] Univ Fed Parana, Dept Farmacol, Ctr Politecn, BR-81531980 Curitiba, Parana, Brazil

来源：

NEUROTOXICITY RESEARCH | 2016年 / 29卷 / 01期

关键词：

Exercise; MPTP; Parkinson's disease; Cognition; Dopamine D2 receptor; CHRONIC MOUSE MODEL; PARKINSONS-DISEASE; TREADMILL EXERCISE; ENDURANCE EXERCISE; RECEPTOR-BINDING; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; BEHAVIORAL RECOVERY; BASAL GANGLIA; D2; RECEPTOR; DEFICITS;

D O I：

10.1007/s12640-015-9566-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The classical motor symptoms of Parkinson's disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuroprotection. We investigated the neuroprotective and disease-modifying potential of physical exercise in a preclinical animal model of PD. C57BL/6 mice (adult males) ran on a horizontal treadmill for 6 weeks (moderate intensity, 5 times/week) and were treated intranasally with 65 mg/kg of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Exercise did not protect against MPTP-induced nigrostriatal neurodegeneration or frontostriatal dopamine depletion but decreased striatal dopamine turnover. Exercise also attenuated procedural and working memory impairment and D-2 receptor hypersensitivity in MPTP-treated mice. In summary, exercise improved dopaminergic neurotransmission and enhanced cognition in a preclinical animal model of PD.

引用

页码：118 / 125

页数：8

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