Leukemogenesis by CBF oncoproteins

被引：80

作者：

Friedman, AD ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Pediat Oncol, Baltimore, MD 21218 USA

来源：

LEUKEMIA | 1999年 / 13卷 / 12期

关键词：

CBF; CBF beta-SMMHC; AML1-ETO; TEL-AML1; AML1-MDS1/EVI1;

D O I：

10.1038/sj.leu.2401590

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The AML1 and CBF beta subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBF beta-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

引用

页码：1932 / 1942

页数：11

共 187 条

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