Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population

被引：36

作者：

Kabbara, A

Payet, N

Cottel, D

Frigard, B

Amouyel, P

Lambert, JC

机构：

[1] Inst Pasteur, U INSERM 508, F-59019 Lille, France

[2] Ctr Hosp Geriatr, F-59290 Wasquehal, France

来源：

NEUROSCIENCE LETTERS | 2004年 / 363卷 / 02期

关键词：

CYP46; APOM; Alzheimer's disease; French population;

D O I：

10.1016/j.neulet.2004.03.066

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a complex, multifactorial disorder, probably resulting from an interaction between environmental and genetic factors. Increasing evidence points to a link between cholesterol turnover and AD, suggesting that genes implicated in brain cholesterol homeostasis may be potential candidate genes for AD. With this background, we tested the potential association of the CYP46, APOM and APOF genes with the risk of developing AD. CYP46 encodes the enzyme cholesterol 24-hydrolase, which plays a key role in brain cholesterol turnover, and APOF and APOM encode apolipoproteins belonging to the large lipocalin family, which also includes ApoE. In contrast to two previous reports but in accordance with one other, we were unable to detect an association between an intron 2 polymorphism of CYP46 and AD. We also searched for polymorphisms within the APOM and APOF by dHPLC. We were unable to detect any polymorphisms in the coding and exon/intron sequences of the APOF. Finally, we excluded APOM as a genetic determinant of AD in our large French case control population. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：139 / 143

页数：5

相关论文

共 24 条

[1] Results of a high-resolution genome screen of 437 Alzheimer's Disease families [J].

Blacker, D ;

Bertram, L ;

Saunders, AJ ;

Moscarillo, TJ ;

Albert, MS ;

Wiener, H ;

Perry, RT ;

Collins, JS ;

Harrell, LE ;

Go, RCP ;

Mahoney, A ;

Beaty, T ;

Fallin, MD ;

Avramopoulos, D ;

Chase, GA ;

Folstein, MF ;

McInnis, MG ;

Bassett, SS ;

Doheny, KJ ;

Pugh, EW ;

Tanzi, RE .

HUMAN MOLECULAR GENETICS, 2003, 12 (01) :23-32

[2]

Collins JS, 2000, AM J MED GENET, V96, P823, DOI 10.1002/1096-8628(20001204)96:6<823::AID-AJMG26>3.0.CO

[3]

2-I

[4] Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease [J].

Desai, P ;

DeKosky, ST ;

Kamboh, MI .

NEUROSCIENCE LETTERS, 2002, 328 (01) :9-12

[5] Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis [J].

Farrer, LA ;

Cupples, LA ;

Haines, JL ;

Hyman, B ;

Kukull, WA ;

Mayeux, R ;

Myers, RH ;

PericakVance, MA ;

Risch, N ;

vanDuijn, CM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16) :1349-1356

[6] Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo [J].

Fassbender, K ;

Simons, M ;

Bergmann, C ;

Stroick, M ;

Lütjohann, D ;

Keller, P ;

Runz, H ;

Kühl, S ;

Bertsch, T ;

von Bergmannn, K ;

Hennerici, M ;

Beyreuther, K ;

Hartmann, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5856-5861

[7] Human leucocyte antigen-A2 increases risk of Alzheimer's disease but does not affect age of onset in a Scottish population [J].

Harris, JM ;

Cumming, AM ;

Craddock, N ;

St Clair, D ;

Lendon, CL .

NEUROSCIENCE LETTERS, 2000, 294 (01) :37-40

[8] No synergistic effect between -850 tumor necrosis factor-α promoter polymorphism and apolipoprotein E ε4 allele in Alzheimer's disease [J].

Infante, J ;

Llorca, J ;

Berciano, J ;

Combarros, O .

NEUROSCIENCE LETTERS, 2002, 328 (01) :71-73

[9] Statins and the risk of dementia [J].

Jick, H ;

Zornberg, GL ;

Jick, SS ;

Seshadri, S ;

Drachman, DA .

LANCET, 2000, 356 (9242) :1627-1631

[10] Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease [J].

Kang, DE ;

Saitoh, T ;

Chen, X ;

Xia, Y ;

Masliah, E ;

Hansen, LA ;

Thomas, RG ;

Thal, LJ ;

Katzman, R .

NEUROLOGY, 1997, 49 (01) :56-61