New reactions in clavulanic acid biosynthesis

被引：50

作者：

Townsend, CA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(02)00392-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clavulanic acid is only a modestly effective antibiotic against bacterial infections in humans, but a potent inhibitor/inactivator of beta-lactamase enzymes that confer bacterial resistance. The biosynthetic pathway to clavulanic acid is considerably more complex than that to the structurally related penicillins and cephalosporins and has revealed several interesting reactions.

引用

页码：583 / 589

页数：7

共 44 条

[1] CLONING, SEQUENCING AND DISRUPTION OF A GENE FROM STREPTOMYCES-CLAVULIGERUS INVOLVED IN CLAVULANIC ACID BIOSYNTHESIS
AIDOO, KA
WONG, A
ALEXANDER, DC
RITTAMMER, RAR
JENSEN, SE
[J]. GENE, 1994, 147 (01) : 41 - 46
[2] Kinetic mechanism of the β-lactam synthetase of Streptomyces clavuligerus
Bachmann, BO
Townsend, CA
[J]. BIOCHEMISTRY, 2000, 39 (37) : 11187 - 11193
[3] β-Lactam synthetase:: A new biosynthetic enzyme
Bachmann, BO
Li, RF
Townsend, CA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) : 9082 - 9086
[4] Chemistry and biosynthesis of clavulanic acid and other clavams
Baggaley, KH
Brown, AG
Schofield, CJ
[J]. NATURAL PRODUCT REPORTS, 1997, 14 (04) : 309 - 333
[5] CLONING A STREPTOMYCES-CLAVULIGERUS GENETIC-LOCUS INVOLVED IN CLAVULANIC ACID BIOSYNTHESIS
BAILEY, CR
BUTLER, MJ
NORMANSELL, ID
ROWLANDS, RT
WINSTANLEY, DJ
[J]. BIO-TECHNOLOGY, 1984, 2 (09): : 808 - 811
[6] A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID
BALDWIN, JE
LLOYD, MD
WHASON, B
SCHOFIELD, CJ
ELSON, SW
BAGGALEY, KH
NICHOLSON, NH
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (06) : 500 - 502
[7] STEREOCHEMICAL COURSE OF THE KEY RING-FORMING REACTIONS IN CLAVULANIC ACID BIOSYNTHESIS
BASAK, A
SALOWE, SP
TOWNSEND, CA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (04) : 1654 - 1656
[8] FROM CRYSTAL STATICS TO CHEMICAL-DYNAMICS
BURGI, HB
DUNITZ, JD
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1983, 16 (05) : 153 - 161
[9] A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations
Busby, RW
Townsend, CA
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (07) : 1059 - 1064
[10] Biosynthetic pathways - Biosynthesis meets bioinformatics
Cane, DE
[J]. SCIENCE, 2000, 287 (5454) : 818 - 819

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