Cytochrome P450-catalyzed oxidation of halobenzene derivatives

被引:55
作者
Rietjens, IMCM
denBesten, C
Hanzlik, RP
vanBladeren, PJ
机构
[1] DUPHAR BV,DEPT DRUG SAFETY,NL-1381 CP WEESP,NETHERLANDS
[2] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045
[3] UNIV AGR,DEPT TOXICOL,NL-6703 HE WAGENINGEN,NETHERLANDS
[4] TNO,NUTR & FOOD RES INST,ZEIST,NETHERLANDS
关键词
D O I
10.1021/tx9601061
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:629 / 635
页数:7
相关论文
共 52 条
[1]   METABOLISM OF PENTACHLOROPHENOL INVIVO AND INVITRO [J].
AHLBORG, UG ;
LARSSON, K ;
THUNBERG, T .
ARCHIVES OF TOXICOLOGY, 1978, 40 (01) :45-53
[2]   POSSIBLE MECHANISM OF LIVER NECROSIS CAUSED BY AROMATIC ORGANIC COMPOUNDS [J].
BRODIE, BB ;
REID, WD ;
CHO, AK ;
SIPES, G ;
KRISHNA, G ;
GILLETTE, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (01) :160-&
[3]   THE EFFECT OF VARYING HALOGEN SUBSTITUENT PATTERNS ON THE CYTOCHROME-P450 CATALYZED DEHALOGENATION OF 4-HALOGENATED ANILINES TO 4-AMINOPHENOL METABOLITES [J].
CNUBBEN, NHP ;
VERVOORT, J ;
BOERSMA, MG ;
RIETJENS, IMCM .
BIOCHEMICAL PHARMACOLOGY, 1995, 49 (09) :1235-1248
[4]  
DALY JW, 1972, EXPERIENTIA, V28, P1129, DOI 10.1007/BF01946135
[5]   METABOLIC-ACTIVATION OF 1,2,4-TRICHLOROBENZENE AND PENTACHLOROBENZENE BY RAT-LIVER MICROSOMES - A MAJOR ROLE FOR QUINONE METABOLITES [J].
DENBESTEN, C ;
SMINK, MCC ;
DEVRIES, EJ ;
VANBLADEREN, PJ .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 108 (02) :223-233
[6]   THE INVOLVEMENT OF PRIMARY AND SECONDARY METABOLISM IN THE COVALENT BINDING OF 1,2-DICHLOROBENZENES AND 1,4-DICHLOROBENZENES [J].
DENBESTEN, C ;
ELLENBROEK, M ;
VANDERREE, MAE ;
RIETJENS, IMCM ;
VANBLADEREN, PJ .
CHEMICO-BIOLOGICAL INTERACTIONS, 1992, 84 (03) :259-275
[7]   CYTOCHROME-P450-MEDIATED OXIDATION OF PENTAFLUOROPHENOL TO TETRAFLUOROBENZOQUINONE AS THE PRIMARY REACTION-PRODUCT [J].
DENBESTEN, C ;
VANBLADEREN, PJ ;
DUIZER, E ;
VERVOORT, J ;
RIETJENS, IMCM .
CHEMICAL RESEARCH IN TOXICOLOGY, 1993, 6 (05) :674-680
[8]   THE METABOLISM OF PENTACHLOROBENZENE BY RAT-LIVER MICROSOMES - THE NATURE OF THE REACTIVE INTERMEDIATES FORMED [J].
DENBESTEN, C ;
PETERS, MMCG ;
VANBLADEREN, PJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (03) :1275-1281
[9]   COVALENT BINDING OF TRANS-STILBENE TO RAT-LIVER MICROSOMES [J].
DOCKS, EL ;
KRISHNA, G .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (21) :1965-1969
[10]   REDOX CYCLING AND SULFHYDRYL ARYLATION - THEIR RELATIVE IMPORTANCE IN THE MECHANISM OF QUINONE CYTO-TOXICITY TO ISOLATED HEPATOCYTES [J].
GANT, TW ;
RAO, DNR ;
MASON, RP ;
COHEN, GM .
CHEMICO-BIOLOGICAL INTERACTIONS, 1988, 65 (02) :157-173