Cytochrome P450-catalyzed oxidation of halobenzene derivatives

被引:55
作者
Rietjens, IMCM
denBesten, C
Hanzlik, RP
vanBladeren, PJ
机构
[1] DUPHAR BV,DEPT DRUG SAFETY,NL-1381 CP WEESP,NETHERLANDS
[2] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045
[3] UNIV AGR,DEPT TOXICOL,NL-6703 HE WAGENINGEN,NETHERLANDS
[4] TNO,NUTR & FOOD RES INST,ZEIST,NETHERLANDS
关键词
D O I
10.1021/tx9601061
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:629 / 635
页数:7
相关论文
共 52 条
[31]   STEREOSELECTIVE FORMATION OF BROMOBENZENE GLUTATHIONE CONJUGATES [J].
MONKS, TJ ;
POHL, LR ;
GILLETTE, JR ;
HONG, M ;
HIGHET, RJ ;
FERRETTI, JA ;
HINSON, JA .
CHEMICO-BIOLOGICAL INTERACTIONS, 1982, 41 (02) :203-216
[32]   BROMOBENZENE AND PARA-BROMOPHENOL TOXICITY AND COVALENT BINDING INVIVO [J].
MONKS, TJ ;
HINSON, JA ;
GILLETTE, JR .
LIFE SCIENCES, 1982, 30 (10) :841-848
[33]   NEPHROTOXICITY OF QUINOL QUINONE-LINKED S-CONJUGATES [J].
MONKS, TJ ;
LAU, SS .
TOXICOLOGY LETTERS, 1990, 53 (1-2) :59-67
[34]   OXIDATIVE DEHALOGENATION OF 2-FLUORO-17-ALPHA-ETHYNYLOESTRADIOL INVIVO - A DISTAL STRUCTURE-METABOLISM RELATIONSHIP OF 17-ALPHA-ETHYNYLATION [J].
MORGAN, P ;
MAGGS, JL ;
PAGE, PCB ;
PARK, BK .
BIOCHEMICAL PHARMACOLOGY, 1992, 44 (09) :1717-1724
[35]   APPLICATION OF CHEMICAL P450 MODEL SYSTEMS TO STUDY ON DRUG-METABOLISM .9. NOVEL OXIDATIVE PATHWAY OF PARASUBSTITUTED PHENOLS IN CYTOCHROME-P450 CHEMICAL-MODEL - SUBSTITUENT ELIMINATION ACCOMPANYING IPSO-SUBSTITUTION BY THE OXYGEN-ATOM OF THE ACTIVE SPECIES [J].
OHE, T ;
MASHINO, T ;
HIROBE, M .
TETRAHEDRON LETTERS, 1995, 36 (42) :7681-7684
[36]   COMPARATIVE METABOLISM OF 7,12-DIMETHYLBENZ[A]-ANTHRACENE AND ITS NON-CARCINOGENIC 2-FLUORO ANALOG BY SYRIAN-HAMSTER EMBRYO CELLS [J].
ORAVEC, CT ;
DANIEL, FB ;
WONG, LK .
CANCER LETTERS, 1983, 21 (01) :43-55
[37]  
POWIS G, 1987, CANCER RES, V47, P2363
[38]   METABOLIC STUDIES ON PENTACHLOROPHENOL (PCP) IN RATS [J].
RENNER, G ;
HOPFER, C .
XENOBIOTICA, 1990, 20 (06) :573-582
[39]   REACTION PATHWAYS FOR BIODEHALOGENATION OF FLUORINATED ANILINES [J].
RIETJENS, IMCM ;
TYRAKOWSKA, B ;
VEEGER, C ;
VERVOORT, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 194 (03) :945-954
[40]   A NEW HYPOTHESIS FOR THE MECHANISM FOR CYTOCHROME-P-450 DEPENDENT AEROBIC CONVERSION OF HEXAHALOGENATED BENZENES TO PENTAHALOGENATED PHENOLS [J].
RIETJENS, IMCM ;
VERVOORT, J .
CHEMICAL RESEARCH IN TOXICOLOGY, 1992, 5 (01) :10-19