APPLICATION OF CHEMICAL P450 MODEL SYSTEMS TO STUDY ON DRUG-METABOLISM .9. NOVEL OXIDATIVE PATHWAY OF PARASUBSTITUTED PHENOLS IN CYTOCHROME-P450 CHEMICAL-MODEL - SUBSTITUENT ELIMINATION ACCOMPANYING IPSO-SUBSTITUTION BY THE OXYGEN-ATOM OF THE ACTIVE SPECIES

被引：31

作者：

OHE, T ^{[1
]}

MASHINO, T ^{[1
]}

HIROBE, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 42期

关键词：

D O I：

10.1016/0040-4039(95)01611-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The meso-tetrakis(2,6-difluorophenyl)porphinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [O-18]mCPBA proved that these reactions are accompanied with ipso-substitution by the oxygen atom of the active species of the P450 model.

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页码：7681 / 7684

页数：4

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