APPLICATION OF CHEMICAL-P-450 MODEL SYSTEMS TO STUDY ON DRUG-METABOLISM .5. OXIDATIVE DECARBOXYLATION OF CARBOXYLIC-ACIDS BY IRON PORPHYRIN IODOSYLBENZENE SYSTEM

被引：51

作者：

KOMURO, M ^{[1
]}

NAGATSU, Y ^{[1
]}

HIGUCHI, T ^{[1
]}

HIROBE, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,HONGO,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)61242-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iodosylbenzene - iron tetraarylporphyrin catalyst system decarboxylated alpha-aryl carboxylic acids and alpha,alpha,alpha-trisubstituted acetic acids efficiently to give the corresponding alcohol and carbonyl derivatives.

引用

页码：4949 / 4952

页数：4

共 16 条

[1] HIGH-VALENT IRON-PORPHYRIN COMPLEXES RELATED TO PEROXIDASE AND CYTOCHROME-P-450 [J].

GROVES, JT ;

HAUSHALTER, RC ;

NAKAMURA, M ;

NEMO, TE ;

EVANS, BJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (10) :2884-2886

[2] HYDROXYLATION AND EPOXIDATION CATALYZED BY IRON-PORPHINE COMPLEXES - OXYGEN-TRANSFER FROM IODOSYLBENZENE [J].

GROVES, JT ;

NEMO, TE ;

MYERS, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (04) :1032-1033

[3] EPOXIDATION REACTIONS CATALYZED BY IRON PORPHYRINS - OXYGEN-TRANSFER FROM IODOSYLBENZENE [J].

GROVES, JT ;

NEMO, TE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (18) :5786-5791

[4]

HIROBE M, 1990, CHEM PHARM BULL, V38, P400

[5] ELECTRONIC-SPECTRA OF TETRAPHENYLPORPHINATOIRON(III) METHOXIDE [J].

KOBAYASHI, H ;

HIGUCHI, T ;

KAIZU, Y ;

OSADA, H ;

AOKI, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1975, 48 (11) :3137-3141

[6] THIOPHENE S-OXIDES AS NEW REACTIVE METABOLITES - FORMATION BY CYTOCHROME-P450 DEPENDENT OXIDATION AND REACTION WITH NUCLEOPHILES [J].

MANSUY, D ;

VALADON, P ;

ERDELMEIER, I ;

LOPEZGARCIA, P ;

AMAR, C ;

GIRAULT, JP ;

DANSETTE, PM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (20) :7825-7826

[7] BIOMIMETIC CATALYSTS FOR SELECTIVE OXIDATION IN ORGANIC-CHEMISTRY [J].

MANSUY, D .

PURE AND APPLIED CHEMISTRY, 1990, 62 (04) :741-746

[8] CYTOCHROME-P-450 AND SYNTHETIC MODELS [J].

MANSUY, D .

PURE AND APPLIED CHEMISTRY, 1987, 59 (06) :759-770

[9] CHEMICAL-MODEL SYSTEMS FOR DRUG-METABOLIZING CYTOCHROME-P-450-DEPENDENT MONOOXYGENASES [J].

MANSUY, D ;

BATTIONI, P ;

BATTIONI, JP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 184 (02) :267-285

[10]

MASUMOTO H, 1991, DRUG METAB DISPOS, V19, P768

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