APPLICATION OF CHEMICAL-P-450 MODEL SYSTEMS TO STUDY ON DRUG-METABOLISM .5. OXIDATIVE DECARBOXYLATION OF CARBOXYLIC-ACIDS BY IRON PORPHYRIN IODOSYLBENZENE SYSTEM

被引：51

作者：

KOMURO, M ^{[1
]}

NAGATSU, Y ^{[1
]}

HIGUCHI, T ^{[1
]}

HIROBE, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,HONGO,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)61242-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iodosylbenzene - iron tetraarylporphyrin catalyst system decarboxylated alpha-aryl carboxylic acids and alpha,alpha,alpha-trisubstituted acetic acids efficiently to give the corresponding alcohol and carbonyl derivatives.

引用

页码：4949 / 4952

页数：4

共 16 条

[11]

MASUMOTO H, 1989, CHEM PHARM BULL, V37, P1788

[12]

MCMURRY TJ, 1986, CYTOCHROME P450 STRU, pCH1

[13] APPLICATION OF CHEMICAL P-450 MODEL SYSTEMS TO STUDY DRUG-METABOLISM .3. METABOLISM OF 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO[1,5-A]PYRIDINE [J].

NAGATSU, Y ;

HIGUCHI, T ;

HIROBE, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (02) :400-403

[14]

NAGATSU Y, 1989, CHEM PHARM BULL, V37, P1410

[15]

VANDERMADE AW, 1988, RECL TRAV CHIM PAY B, V107, P15

[16] REACTION OF CYCLOHEXENE WITH IODOSYLBENZENE CATALYZED BY NONPORPHYRIN COMPLEXES OF IRON(III) AND ALUMINUM(III) - NEWLY DISCOVERED PRODUCTS AND A NEW MECHANISTIC PROPOSAL [J].

YANG, YH ;

DIEDERICH, F ;

VALENTINE, JS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (21) :7826-7828

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