Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention

被引：87

作者：

Davis, CD ^{[1
]}

Milner, J ^{[1
]}

机构：

[1] NCI, NIH, Nutrit Sci Res Grp, Bethesda, MD 20892 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2004年 / 551卷 / 1-2期

关键词：

nutrigenetics; nutritional transcriptomics; proteomics; metabolomics; cancer prevention;

D O I：

10.1016/j.mrfmmm.2004.01.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

While dietary habits continue to surface as a significant factor that may influence cancer incidence and tumor behavior, there is considerable scientific uncertainty about who will benefit most. Inadequate knowledge about how the responses depend on an individual's genetic background (nutrigenetic effects), the cumulative effects of food components on genetic expression profiles (nutritional transcriptomics and nutritional epigenomics effects), the occurrence and activity of proteins (proteomic effects) and/or the dose and temporal changes in cellular small molecular weight compounds (metabolomics effects) may assist in identifying responders and non-responders. Expanding the information about similarities and differences in the "omic" responses across tissues will not only provide clues about specificity in response to bioactive food components but assist in the identification of surrogate tissues and biomarkers that can be used for predicting a response. Deciphering the importance of each of these potential sites of regulation will be particularly challenging but does hold promise in explaining many of the inconsistencies in the literature. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：51 / 64

页数：14

共 104 条

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