In vitro biosynthetic studies of the bryostatins, anti-cancer agents from the marine bryozoan Bugula neritina.

被引：19

作者：

Kerr, RG

Lawry, J

Gush, KA

机构：

[1] Dept. of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 46期

关键词：

D O I：

10.1016/0040-4039(96)01943-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acetate, S- adenosylmethionine and glycerol have been identified as key building blocks of the anticancer polyketide, bryostatin 1, through a series of in vitro biosynthetic experiments. The active enzyme preparation was fortified with ATP, Mg2+, NADH and NADPH. Copyright (C) 1996 Elsevier Science Ltd

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页码：8305 / 8308

页数：4

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