Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy

被引:13
作者
Seko, Y
Ishiyama, S
Nishikawa, T
Kasajima, T
Hiroe, M
Suzuki, S
Ishiwata, S
Kawai, S
Tanaka, Y
Azuma, M
Kobata, T
Yagita, H
Okumura, K
Nagai, R
机构
[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
[2] Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan
[3] Asahi Life Fdn, Inst Adult Dis, Tokyo, Japan
[4] Tokyo Womens Med Coll, Dept Pathol 2, Tokyo 162, Japan
[5] Tokyo Med & Dent Univ, Sch Med, Dept Internal Med 2, Tokyo 113, Japan
[6] Sakakibara Heart Inst, Dept Cardiol, Tokyo, Japan
[7] Toranomon Gen Hosp, Ctr Cardiovasc, Dept Cardiol, Tokyo, Japan
[8] Juntendo Univ, Sch Med, Dept Internal Med, Div Cardiol, Tokyo 113, Japan
[9] Kitasato Univ, Sch Sci, Dept Biosci, Kanagawa, Japan
[10] Natl Childrens Med Res Ctr, Dept Immunol, Tokyo 154, Japan
关键词
myocarditis; dilated cardiomyopathy; costimulatory molecule; TNF receptor/ligand superfamily; T-cell;
D O I
10.1016/S1054-8807(02)00101-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: T-cell-mediated myocardial damage is known to be involved in acute myocarditis and dilated cardiomyopathy. Recently, we found that tumor necrosis factor (TNF) ligand superfamily costimulatory molecules, especially 4-1BBL, played an important role in the myocardial damage of murine acute viral myocarditis. Methods and results: To investigate the roles for CD27L, CD30L, OX40L and 4-1BBL, which belong to TNF ligand superfamily, in the development of acute myocarditis and dilated cardiomyopathy, we analyzed the expression of these antigens in the myocardial tissues of patients with acute myocarditis and dilated cardiomyopathy. We also examined expression of the receptors for these molecules, CD27, CD30, OX40 and 4-1BB, which belong to TNF receptor superfamily, on the infiltrating cells. Strong expression of CD27L, CD30L and 4-1BBL and weak to moderate expression of OX40L was found in the cardiac myocytes of patients with acute myocarditis. Moderate expression of CD27L, CD30L and 4-1BBL and weak expression of OX40L was found on the cardiac myocytes of patients with dilated cardiomyopathy. Most of the infiltrating cells expressed CD27, CD30 and 4-1BB and a part of the infiltrating cells expressed OX40. Conclusions: Our Findings suggest that expression of TNF ligand superfamily costimulatory molecules on cardiac myocytes may play a role in the cell-mediated myocardial damage in patients with acute myocarditis and dilated cardiomyopathy as in murine viral myocarditis. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:166 / 170
页数:5
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