Use of olefin templates in queued chemical transformations using late transition metal catalysis.: Total synthesis of cis and trans bupleurynol via a single multireaction sequence

被引：23

作者：

Ghasemi, H ^{[1
]}

Antunes, LM ^{[1
]}

Organ, MG ^{[1
]}

机构：

[1] York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 17期

关键词：

D O I：

10.1021/ol0489853

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Bromo-2-iodoethylene (9) was used as a central, pseudosymmetric building block for the fully convergent and modular synthesis of two related natural products, cis (1a) and trans (1b) bupleurynol. In doing so, a 9-step synthesis of la (reported previously) has been vastly truncated to one single operation by using queued cross-coupling reactions with Pd catalysis, negating the need for any protecting group chemistry.

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页码：2913 / 2916

页数：4

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