Toxicity in head and neck cancer: A review of trends and issues

被引:260
作者
Trotti, A [1 ]
机构
[1] Univ S Florida, H Lee Moffitt Canc Ctr, Div Radiat Oncol, Tampa, FL 33612 USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2000年 / 47卷 / 01期
关键词
toxicity; acute effects; late effects; adverse events; morbidity;
D O I
10.1016/S0360-3016(99)00558-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The quest for improved fractionation and combined modality regimens in head and neck cancer has also yielded progressively higher rates of toxicity. Time compression of dose delivery in accelerated fractionation has produced high rates of severe mucositis including the early stoppage of two randomized trials. The addition of chemotherapy has introduced systemic toxicity and can exacerbate local tissue reactions when used concurrent with radiotherapy. Mucositis is recognized as the principal impediment to efforts at further treatment intensification. The development and utilization of standardized toxicity grading criteria and accepted reporting standards has lagged toxicity production, impeding a full appreciation of the true extent of both acute and late toxicity. Objective data regarding acute and chronic effects on organ function are also sorely lacking. A better characterization of the frequency, severity, and duration of the various toxicities encountered in head and neck cancer will also allow the rational development of toxicity interventions. New methods are needed to summarize the global or aggregate toxicity of a treatment program. Further research into the assessment and analysis of toxicity is not only crucial to improvements in quality of life (QOL), but perhaps, improved rates of disease control as well. (C) 2000 Elsevier Science Inc.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 96 条
[81]  
RUBIN P, 1995, 9604 RTOG HEADQ
[82]   SINGLE FRACTION PER DAY VERSUS 2 FRACTIONS PER DAY VERSUS RADIOCHEMOTHERAPY IN THE TREATMENT OF HEAD AND NECK-CANCER [J].
SANCHIZ, F ;
MILLA, A ;
TORNER, J ;
BONET, F ;
ARTOLA, N ;
CARRENO, L ;
MOYA, LM ;
RIERA, D ;
RIPOL, S ;
CIRERA, L .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 19 (06) :1347-1350
[83]   COMPLICATIONS FOLLOWING SURGERY FOR CANCER OF THE LARYNX AND PYRIFORM FOSSA [J].
SARKAR, S ;
MEHTA, SA ;
TIWARI, J ;
MEHTA, AR ;
MEHTA, MS .
JOURNAL OF SURGICAL ONCOLOGY, 1990, 43 (04) :245-249
[84]  
SASSLER AM, 1995, ARCH OTOLARYNGOL, V121, P162
[85]   Randomised multicentre trials of CHART vs conventional radiotherapy in head and neck and non-small-cell lung cancer: An interim report [J].
Saunders, MI ;
Dische, S ;
Barrett, A ;
Parmar, MKB ;
Harvey, A ;
Gibson, D .
BRITISH JOURNAL OF CANCER, 1996, 73 (12) :1455-1462
[86]   Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity [J].
Sonis, ST .
ORAL ONCOLOGY, 1998, 34 (01) :39-43
[87]  
Sonis ST, 1999, CANCER-AM CANCER SOC, V85, P2103, DOI 10.1002/(SICI)1097-0142(19990515)85:10<2103::AID-CNCR2>3.0.CO
[88]  
2-0
[89]   RANDOMIZED COMPARISON OF NEOADJUVANT CISPLATIN AND FLUOROURACIL INFUSION FOLLOWED BY RADIATION VERSUS CONCOMITANT TREATMENT IN ADVANCED HEAD AND NECK-CANCER [J].
TAYLOR, SG ;
MURTHY, AK ;
VANNETZEL, JM ;
COLIN, P ;
DRAY, M ;
CALDARELLI, DD ;
SHOTT, S ;
VOKES, E ;
SHOWEL, JL ;
HUTCHINSON, JC ;
WITT, TR ;
GRIEM, KL ;
HARTSELL, WF ;
KIES, MS ;
MITTAL, B ;
REBISCHUNG, JL ;
COUPEZ, DJ ;
DESPHIEUX, JL ;
BOBIN, S ;
LEPAJOLEC, C .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (02) :385-395
[90]  
Terrell JE, 1997, ARCH OTOLARYNGOL, V123, P1125