Preparation of enantiomerically enriched aromatic β-amino acids via enzymatic resolution

被引：46

作者：

Faulconbridge, SJ

Holt, KE

Sevillano, LG

Lock, CJ

Tiffin, PD

Tremayne, N

Winter, S

机构：

[1] Celltech Chirosci Ltd, Cambridge CB4 0WG, England

[2] Chirotech Technol Ltd, Cambridge CB4 0WG, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 15期

关键词：

amino acids and derivatives; asymmetric synthesis; enzymes and enzyme reactions; resolution;

D O I：

10.1016/S0040-4039(00)00222-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of enantiomerically enriched aromatic beta-amino acids with high e.e. have been prepared via enzymatic resolution of ethyl ester derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2679 / 2681

页数：3

共 7 条

[1] HYDROLYSIS OF D(-)-ETHYL BETA-PHENYL-BETA-HYDROXYPROPIONATE + D)-)-ETHYL BETA-PHENYL-BETA-ACETAMIDOPROPIONATE BY ALPHA-CHYMOTRYPSIN [J].

COHEN, SG ;

WEINSTEIN, SY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (04) :725-&

[2]

JUARISTI E, 1996, ENANTIOSELECTIVE SYN

[3]

Ng J S, 1998, Curr Opin Drug Discov Devel, V1, P314

[4] SYNTHESIS OF (S)-4-[(METHOXYCARBONYL)METHYL]-2-AZETIDINONE AND (R)-4-[(METHOXYCARBONYL)METHYL]-2-AZETIDINONE BY CHEMICOENZYMATIC APPROACH [J].

OHNO, M ;

KOBAYASHI, S ;

IIMORI, T ;

WANG, YF ;

IZAWA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (09) :2405-2406

[5]

RODIONOV VM, 1929, J AM CHEM SOC, V51, P841

[6] BIOCATALYTIC APPROACH TO ENANTIOMERICALLY PURE BETA-AMINO ACIDS [J].

SOLOSHONOK, VA ;

FOKINA, NA ;

RYBAKOVA, AV ;

SHISHKINA, IP ;

GALUSHKO, SV ;

SOROCHINSKY, AE ;

KUKHAR, VP ;

SAVCHENKO, MV ;

SVEDAS, VK .

TETRAHEDRON-ASYMMETRY, 1995, 6 (07) :1601-1610

[7]

SOLOSHONOK VA, 1996, ENANTIOSELECTIVE SYN, P443

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