Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity

被引：104

作者：

Chen, Tingting ^{[2
,3
]}

Wang, Xiaoyong ^{[1
]}

He, Yafeng ^{[2
]}

Zhang, Changli ^{[2
]}

Wu, Ziyi ^{[2
]}

Liao, Kuo ^{[2
]}

Wang, Jianjun ^{[4
]}

Guo, Zijian ^{[2
]}

机构：

[1] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

[3] Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China

[4] Wayne State Univ, Sch Med, Detroit, MI 48202 USA

来源：

INORGANIC CHEMISTRY | 2009年 / 48卷 / 13期

关键词：

MACROCYCLIC TETRA-AMINES; ALZHEIMER A-BETA; METAL-IONS; NEURODEGENERATIVE DISEASES; MOLECULAR-MECHANISMS; PARKINSONS-DISEASES; HYDROGEN-PEROXIDE; TRANSGENIC MICE; CLEAVAGE AGENTS; SENILE PLAQUES;

D O I：

10.1021/ic900025x

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Amyloid beta-peptide (A beta) aggregation is highly associated with Alzheimer's disease, which is facilitated by Zn2+ and Cu2+. Macrocyclic polyamine chelators cyclen and cyclam, can effectively protect A beta against precipitation induced by Cu2+ or Zn2+; the production of H2O2 mediated by Cu-A beta can also be inhibited by these chelators.

引用

页码：5801 / 5809

页数：9

共 59 条

[51] EVALUATION OF LD50 OF SOME MACROCYCLIC DRUGS AND THEIR LINEAR ANALOGS USED AS CHELATING DRUGS IN METAL INTOXICATION
SRIVASTAVA, A
KATIYAR, SS
BEHARI, JR
HASAN, SK
SRIVASTAVA, SK
SRIVASTAVA, RC
[J]. CHEMOSPHERE, 1988, 17 (04) : 839 - 844
[52] Cleavage agents for soluble oligomers of amyloid β peptides
Suh, Junghun
Yoo, Sang Ho
Kim, Min Gyum
Jeong, Keunhong
Ahn, Jae Young
Kim, Myoung-Soon
Chae, Pil Seok
Lee, Tae Yeon
Lee, Jaehwa
Lee, Jeongkuk
Jang, Yun Ah
Ko, Eun Hwa
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (37) : 7064 - 7067
[53] Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
Suh, SW
Jensen, KB
Jensen, MS
Silva, DS
Kesslak, PJ
Danscher, G
Frederickson, CJ
[J]. BRAIN RESEARCH, 2000, 852 (02) : 274 - 278
[54] Takahashi Y, 1998, CHEM-EUR J, V4, P2475, DOI 10.1002/(SICI)1521-3765(19981204)4:12<2475::AID-CHEM2475>3.3.CO
[55] 2-E
[56] Zinc binding to amyloid-β:: Isothermal titration calorimetry and Zn competition experiments with Zn sensors
Talmard, Christine
Bouzan, Anais
Faller, Peter
[J]. BIOCHEMISTRY, 2007, 46 (47) : 13658 - 13666
[57] Methylation of the imidazole side chains of the Alzheimer disease amyloid-β peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity
Tickler, AK
Smith, DG
Ciccotosto, GD
Tew, DJ
Curtain, CC
Carrington, D
Masters, CL
Bush, AI
Cherny, RA
Cappai, R
Wade, JD
Barnham, KJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (14) : 13355 - 13363
[58] Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-β peptide
Tougu, Vello
Karafin, Ann
Palumaa, Peep
[J]. JOURNAL OF NEUROCHEMISTRY, 2008, 104 (05) : 1249 - 1259
[59] Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents
Wu, Wei-hui
Lei, Peng
Liu, Qian
Hu, Jia
Gunn, Adam P.
Chen, Mei-sha
Rui, Yan-fang
Su, Xiao-yang
Xie, Zuo-ping
Zhao, Yu-Fen
Bush, Ashley I.
Li, Yan-mei
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (46) : 31657 - 31664

← 1 2 3 4 5 6 →